Background
Catalog Number:
CPTC-FHL1-1
RRID:
AB_2884019
Target Antigen:
Four And A Half LIM Domains 1 Peptide 1
Isotype:
IgG
Species:
Rabbit Recombinant Cloned Antibody
Last Updated:
08/23/2022
Antigen Recognition(s):
Peptide
Purchase
- DSHB CPTC-FHL1-1
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (291.7 KB)
CPTC-FHL1-1 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
Immuno-MRM
CPTC-FHL1-1 iMRM data
Result: Positive
iMRM data obtained using antibody CPTC-FHL1-1 to immuno-precipitate peptide AIVAGDQNVEYK (CPTC-FHL1 Peptide 1)
Data provided by the Carr Lab, Broad Institute
https://www.broadinstitute.org/proteomics/protocols
Characterization SOP Files
Western Blot - Recombinant Protein or Peptide
CPTC-FHL1-1 Recombinant protein WB
Result: Negative
Automated Western Blot with recombinant FHL protein.
Characterization SOP Files
Background
NCI Identification Number:
00329
Antigen Name:
Four And A Half LIM Domains 1 Peptide 1
CPTC Name:
CPTC-FHL1 Peptide 1
Aliases:
Four And A Half LIM Domains 1; SLIM1; Four And A Half LIM Domains Protein 1; Skeletal Muscle LIM-Protein 1; LIM Protein SLIMMER; SLIM-1; FHL-1; FHL1B; FLH1A; XMPMA; SLIM; Four-And-A-Half Lin11, Isl-1 And Mec-3 Domains 1; Four-And-A-Half LIM Domains 1; BA535K18.1; MGC111107; SLIMMER; RBMX1A; RBMX1B; FCMSU; FHL1A; KYO-T; KYOT; FHL1
Function:
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.FHL1 (Four And A Half LIM Domains 1) is a Protein Coding gene. Diseases associated with FHL1 include Myopathy, X-Linked, With Postural Muscle Atrophy and Scapuloperoneal Myopathy, X-Linked Dominant. Among its related pathways are Notch Signaling Pathway (WikiPathways) and JAK-STAT signaling pathway. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is ZFHX4.May have an involvement in muscle development or hypertrophy.
Chromosomal Localization:
Xq26.3
Accession Number:
NP_001153174.1
UniProt Accession Number:
Q13642
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
AIVAGDQNVEYK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1320
Last Updated:
08/23/2020
Links
- EnsEMBL - EnsEMBL FHL1
- Entrez - Entrez FHL1
- Uniprot - Uniprot Q13642
Characterization Data
SOPs
No SOPs available.
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