Vascular Cell Adhesion Molecule 1 Peptide 1


Background

Catalog Number:

CPTC-VCAM1-1

Target Antigen:

Vascular Cell Adhesion Molecule 1 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

01/11/2021

Antigen Recognition(s):

Peptide, Recombinant Full-length

Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (297.0 KB)

CPTC-VCAM1-1 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


Background

NCI Identification Number:

00401

Antigen Name:

Vascular Cell Adhesion Molecule 1 Peptide 1

CPTC Name:

CPTC-VCAM1 Peptide 1

Keywords:

Vascular Cell Adhesion Molecule 1; Vascular Cell Adhesion Protein 1; CD106 Antigen; INCAM-100; CD106; V-CAM 1; VCAM-1; VCAM1

Function:

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.VCAM1 (Vascular Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with VCAM1 include Viral Encephalitis and Chronic Venous Insufficiency. Among its related pathways are Degradation of the extracellular matrix and Cellular roles of Anthrax toxin. Gene Ontology (GO) annotations related to this gene include integrin binding and primary amine oxidase activity. An important paralog of this gene is MXRA5.Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

Chromosomal Localization:

1p21.2

NCBI Accession Number:

NP_001069.1

UniProt Accession Number:

P19320

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

TQIDSPLSGK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1100

Last Updated:

09/02/2020

Links

Characterization Data

SOPs

No SOPs available.

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