Catalog Number:
CPTC-PMS1-1
RRID:
AB_2890090
Target Antigen:
PMS1 Homolog 1, Mismatch Repair System Component Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
05/17/2024
Antigen Recognition(s):
Peptide
Result: Negative
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Result: Negative
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Result: Negative
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Result: Negative
Western blot using CPTC-PMS1-1 as primary antibody against human PMS1 HEK293T cell transient overexpression lysate (lane 2). Expected molecular weight - 105.7 kDa. Molecular weight standards are also included (lane 1).
Result: Negative
Automated western blot using CPTC-PMS1-1 as primary antibody against buffy coat (lane 2), HeLa (lane 3), Jurkat (lane 4), A549 (lane 5), MCF7 (lane 6), and NCI-H226 (lane 7) whole cell lysates. Expected molecular weight - 105.8 kDa, 86.6 kDa, 101.4 kDa, and 62.9 kDa. Molecular weight standards are also included (lane 1).
Result: Negative
Western blot using CPTC-PMS1-1 as primary antibody against HeLa (lane 2), Jurkat (lane 3), A549 (lane 4), MCF7 (lane 5), and NCI-H226 (lane 6) whole cell lysates. Expected molecular weight - 105.8 kDa, 86.6 kDa, 101.4 kDa, and 62.9 kDa. Molecular weight standards are also included (lane 1).
NCI Identification Number:
00386
Antigen Name:
PMS1 Homolog 1, Mismatch Repair System Component Peptide 1
CPTC Name:
CPTC-PMS1 Peptide 1
Aliases:
PMS1 Homolog 1, Mismatch Repair System Component; DNA Mismatch Repair Protein PMS1; PMS1 Protein Homolog 1; PMSL1; MLH2; PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae); Postmeiotic Segregation Increased (S. Cerevisiae) 1; PMS1 Postmeiotic Segregation Increased 1; Rhabdomyosarcoma Antigen MU-RMS-40.10B; Rhabdomyosarcoma Antigen MU-RMS-40.10E; Human Homolog Of Yeast MutL; Mismatch Repair Gene PMSL1; HNPCC3; HPMS1; PMS1
Function:
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome.PMS1 (PMS1 Homolog 1, Mismatch Repair System Component) is a Protein Coding gene. Diseases associated with PMS1 include Lynch Syndrome I and Lynch Syndrome. Among its related pathways are Mismatch repair. Gene Ontology (GO) annotations related to this gene include ATPase activity and mismatched DNA binding. An important paralog of this gene is PMS2.
Chromosomal Localization:
2q32.2
Accession Number:
NP_000525.1
UniProt Accession Number:
P54277
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
LDELLQSQIEK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1210
Last Updated:
09/02/2020
No SOPs available.
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