Lck Interacting Transmembrane Adaptor 1 Peptide 1


Background

Catalog Number:

CPTC-LIME1-1

Target Antigen:

Lck Interacting Transmembrane Adaptor 1 Peptide 1

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

01/06/2021

Antigen Recognition(s):

Peptide, Phosphorylation

Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (300.0 KB)

CPTC-LIME1-1 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


  IHC Tissue

CTPC-LIME1-1 IHC Tissue

Result: Negative

This antibody is not suitable for use in an Immunohistochemistry format as described in SOP M-106.


Background

NCI Identification Number:

00299

Antigen Name:

Lck Interacting Transmembrane Adaptor 1 Peptide 1

CPTC Name:

CPTC-LIME1 Peptide 1

Keywords:

Lck Interacting Transmembrane Adaptor 1; Lck-Interacting Membrane Protein; Lck-Interacting Molecule; LIME; DJ583P15.4

Function:

This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. LIME1 (Lck Interacting Transmembrane Adaptor 1) is a Protein Coding gene. An important paralog of this gene is ENSG00000273047.Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.

Chromosomal Localization:

20q13.33

NCBI Accession Number:

NP_060276.2

UniProt Accession Number:

Q9H400

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

CSSTC(Cam)GAGT(ph)PPASSC(Cam)PSLGR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

2200

Last Updated:

08/21/2020

Links

Characterization Data

SOPs

No SOPs available.

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