Interleukin 1 Receptor Antagonist Peptide 1


Background

Catalog Number:

CPTC-IL1RN-1

RRID:

AB_2890088

Target Antigen:

Interleukin 1 Receptor Antagonist Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

11/09/2021

Antigen Recognition(s):

Peptide, Recombinant Full-length

Characterization Data [Compare Characterization Data]
  NCI 60 Protein Array

CTPC-IL1RN-1 NCI60 Protein Array

Result: Negative

This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.


Background

NCI Identification Number:

00409

Antigen Name:

Interleukin 1 Receptor Antagonist Peptide 1

CPTC Name:

CPTC-IL1RN Peptide 1

Aliases:

Interleukin 1 Receptor Antagonist; Interleukin-1 Receptor Antagonist Protein; ICIL-1RA; IL-1RN; IL1F3; IL1RA; IRAP; IL1 Inhibitor; IL-1ra; Intracellular Interleukin-1 Receptor Antagonist (IcIL-1ra); Intracellular Interleukin-1 Receptor Antagonist; Intracellular IL-1 Receptor Antagonist Type II; Type II Interleukin-1 Receptor Antagonist; MGC10430; Anakinra; IL-1ra3; MVCD4; IL1RN; DIRA

Function:

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.IL1RN (Interleukin 1 Receptor Antagonist) is a Protein Coding gene. Diseases associated with IL1RN include Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis and Microvascular Complications Of Diabetes 4. Among its related pathways are PEDF Induced Signaling and Prolactin Signaling Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-1 receptor antagonist activity. An important paralog of this gene is IL36RN.Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

Chromosomal Localization:

2q14.1

Accession Number:

NP_776214.1

UniProt Accession Number:

P18510

DNA Source:

N/A

Immunogen:

Recombinant Full Length Protein

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

IDVVPIEPHALFLGIHGGK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

2090

Last Updated:

09/03/2020

Links

Characterization Data

SOPs

No SOPs available.

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