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HRas Proto-Oncogene, GTPase

Antibody: CPTC-HRAS-1
Background

Catalog Number:

CPTC-HRAS-1

Target Antigen:

HRas Proto-Oncogene, GTPase

Isotype:

IgG1

Species:

Mouse Monoclonal Antibody

Last Updated:

10/18/2023

Antigen Recognition(s):

Recombinant Full-length, Endogenous

External Links
Characterization Data [Compare Characterization Data]
  IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (467.3 KB)

CPTC-HRAS-1 evaluation by the Human Protein Atlas

Result: Positive

Results provided by the Human Protein Atlas (www.proteinatlas.org).


Characterization SOP Files

  Immunofluorescence - HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (467.3 KB)

CPTC-HRAS-1 evaluation by the Human Protein Atlas

Result: Negative

Results provided by the Human Protein Atlas (www.proteinatlas.org).


Characterization SOP Files

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Antibody: CPTC-HRAS-2
Background

Catalog Number:

CPTC-HRAS-2

Target Antigen:

HRas Proto-Oncogene, GTPase

Isotype:

IgG2a

Species:

Mouse Monoclonal Antibody

Last Updated:

10/18/2023

Antigen Recognition(s):

Recombinant Full-length, Endogenous

External Links
Characterization Data [Compare Characterization Data]
  IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (518.4 KB)

CPTC-HRAS-2 evaluation by the Human Protein Atlas

Result: Positive

Results provided by the Human Protein Atlas (www.proteinatlas.org).


Characterization SOP Files

  Immunofluorescence - HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (518.4 KB)

CPTC-HRAS-2 evaluation by the Human Protein Atlas

Result: Negative

Results provided by the Human Protein Atlas (www.proteinatlas.org).


Characterization SOP Files

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Antibody: CPTC-HRAS-3
Background

Catalog Number:

CPTC-HRAS-3

Target Antigen:

HRas Proto-Oncogene, GTPase

Isotype:

IgG1

Species:

Mouse Monoclonal Antibody

Last Updated:

10/18/2023

Antigen Recognition(s):

Recombinant Full-length, Endogenous

External Links
Characterization Data [Compare Characterization Data]
  IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (495.5 KB)

CPTC-HRAS-3 evaluation by the Human Protein Atlas

Result: Positive

Results provided by the Human Protein Atlas (www.proteinatlas.org).


Characterization SOP Files

  Immunofluorescence - HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (495.5 KB)

CPTC-HRAS-3 evaluation by the Human Protein Atlas

Result: Negative

Results provided by the Human Protein Atlas (www.proteinatlas.org).


Characterization SOP Files

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Antibody: CPTC-HRAS-4
Background

Catalog Number:

CPTC-HRAS-4

Target Antigen:

HRas Proto-Oncogene, GTPase

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

05/15/2025

Antigen Recognition(s):

Recombinant Full-length

Characterization Data [Compare Characterization Data]
  CyTOF
Click to enlarge image Imaging mass cytometry on ovarian cancer tissue core using CPTC-HRAS-4 metal-labeled antibody. Data shows overlay of target protein signal (red) and DNA (blue). Dilution: 1:100 of 0.5mg/mL stock. Signal was also obtained in other normal tissues (testis, colon, endometrium, appendix, bone marrow, breast, kidney, and lung) and cancer tissues (breast, colon, ovarian, lung, and prostate). Click image to enlarge

CPTC-HRAS-4 Immuno-Mass Cytometry

Result: Positive

Imaging mass cytometry on ovarian cancer tissue core using CPTC-HRAS-4 metal-labeled antibody. Data shows overlay of target protein signal (red) and DNA (blue). Dilution: 1:100 of 0.5mg/mL stock. Signal was also obtained in other normal tissues (testis, colon, endometrium, appendix, bone marrow, breast, kidney, and lung) and cancer tissues (breast, colon, ovarian, lung, and prostate).


Characterization SOP Files

  IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (533.0 KB)

CPTC-HRAS-4 evaluation by the Human Protein Atlas

Result: Negative

Results provided by the Human Protein Atlas (www.proteinatlas.org).


Characterization SOP Files

  IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (533.0 KB)

CPTC-HRAS-4 evaluation by the Human Protein Atlas

Result: Negative

Results provided by the Human Protein Atlas (www.proteinatlas.org).


Characterization SOP Files

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Antigen: HRas Proto-Oncogene, GTPase
Background

NCI Identification Number:

00490

Antigen Name:

HRas Proto-Oncogene, GTPase

CPTC Name:

CPTC-HRAS

Aliases:

HRas Proto-Oncogene, GTPase; V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog; Harvey Rat Sarcoma Viral Oncogene Homolog; Transforming Protein P21; GTPase HRas; P21ras; HRAS1; Ras Family Small GTP Binding Protein H-Ras; Harvey Rat Sarcoma Viral Oncoprotein; Transformation Gene: Oncogene HAMSV; GTP- And GDP-Binding Peptide B; Ha-Ras1 Proto-Oncoprotein; C-Has/Bas P21 Protein; P19 H-RasIDX Protein; EC 3.6.5.2; C-BAS/HAS; C-HA-RAS1; H-RASIDX; C-H-RAS; H-Ras-1; C-H-Ras; Ha-Ras; HAMSV; RASH1; CTLO; HRAS

Function:

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.HRAS (HRas Proto-Oncogene, GTPase) is a Protein Coding gene. Diseases associated with HRAS include Costello Syndrome and Nevus, Epidermal. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and ERK Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and protein C-terminus binding. An important paralog of this gene is KRAS.Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity

Chromosomal Localization:

11p15.5

Expression System:

Baculovirus

Accession Number:

NP_005334.1

UniProt Accession Number:

P01112

DNA Source:

N/A

Immunogen:

Recombinant Full Length Protein

Vector Name:

xx

Extinction Coefficient:

Buffers:

Expressed Sequence:

MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS

Native Sequence:

Calculated Isoelectric Point:

5.16

Molecular Weight:

21355

Last Updated:

11/17/2021

Links

Characterization Data

SOPs

No SOPs available.

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