Background
Catalog Number:
CPTC-HRAS-1
Target Antigen:
HRas Proto-Oncogene, GTPase
Isotype:
IgG1
Species:
Mouse Monoclonal Antibody
Last Updated:
10/18/2023
Antigen Recognition(s):
Recombinant Full-length, Endogenous
External Links
- Human Protein Atlas CPTC-HRAS-1
Characterization Data [Compare Characterization Data]
IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (467.3 KB)
CPTC-HRAS-1 evaluation by the Human Protein Atlas
Result: Positive
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Immunofluorescence - HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (467.3 KB)
CPTC-HRAS-1 evaluation by the Human Protein Atlas
Result: Negative
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Background
Catalog Number:
CPTC-HRAS-2
Target Antigen:
HRas Proto-Oncogene, GTPase
Isotype:
IgG2a
Species:
Mouse Monoclonal Antibody
Last Updated:
10/18/2023
Antigen Recognition(s):
Recombinant Full-length, Endogenous
External Links
- Human Protein Atlas CPTC-HRAS-2
Characterization Data [Compare Characterization Data]
IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (518.4 KB)
CPTC-HRAS-2 evaluation by the Human Protein Atlas
Result: Positive
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Immunofluorescence - HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (518.4 KB)
CPTC-HRAS-2 evaluation by the Human Protein Atlas
Result: Negative
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Background
Catalog Number:
CPTC-HRAS-3
Target Antigen:
HRas Proto-Oncogene, GTPase
Isotype:
IgG1
Species:
Mouse Monoclonal Antibody
Last Updated:
10/18/2023
Antigen Recognition(s):
Recombinant Full-length, Endogenous
External Links
- Human Protein Atlas CPTC-HRAS-3
Characterization Data [Compare Characterization Data]
IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (495.5 KB)
CPTC-HRAS-3 evaluation by the Human Protein Atlas
Result: Positive
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Immunofluorescence - HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (495.5 KB)
CPTC-HRAS-3 evaluation by the Human Protein Atlas
Result: Negative
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Background
Catalog Number:
CPTC-HRAS-4
Target Antigen:
HRas Proto-Oncogene, GTPase
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
10/20/2023
Antigen Recognition(s):
Recombinant Full-length
Characterization Data [Compare Characterization Data]
IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (533.0 KB)
CPTC-HRAS-4 evaluation by the Human Protein Atlas
Result: Negative
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (533.0 KB)
CPTC-HRAS-4 evaluation by the Human Protein Atlas
Result: Negative
Results provided by the Human Protein Atlas (www.proteinatlas.org).
Characterization SOP Files
Background
NCI Identification Number:
00490
Antigen Name:
HRas Proto-Oncogene, GTPase
CPTC Name:
CPTC-HRAS
Aliases:
HRas Proto-Oncogene, GTPase; V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog; Harvey Rat Sarcoma Viral Oncogene Homolog; Transforming Protein P21; GTPase HRas; P21ras; HRAS1; Ras Family Small GTP Binding Protein H-Ras; Harvey Rat Sarcoma Viral Oncoprotein; Transformation Gene: Oncogene HAMSV; GTP- And GDP-Binding Peptide B; Ha-Ras1 Proto-Oncoprotein; C-Has/Bas P21 Protein; P19 H-RasIDX Protein; EC 3.6.5.2; C-BAS/HAS; C-HA-RAS1; H-RASIDX; C-H-RAS; H-Ras-1; C-H-Ras; Ha-Ras; HAMSV; RASH1; CTLO; HRAS
Function:
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.HRAS (HRas Proto-Oncogene, GTPase) is a Protein Coding gene. Diseases associated with HRAS include Costello Syndrome and Nevus, Epidermal. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and ERK Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and protein C-terminus binding. An important paralog of this gene is KRAS.Involved in the activation of Ras protein signal transduction (PubMed:22821884). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
Chromosomal Localization:
11p15.5
Expression System:
Baculovirus
Accession Number:
NP_005334.1
UniProt Accession Number:
P01112
DNA Source:
N/A
Immunogen:
Recombinant Full Length Protein
Vector Name:
xx
Extinction Coefficient:
Buffers:
Expressed Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQI
KRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQ
GVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS
Native Sequence:
Calculated Isoelectric Point:
5.16
Molecular Weight:
21355
Last Updated:
11/17/2021
Links
- EnsEMBL - EnsEMBL HRAS
- Entrez - Entrez HRAS
- Uniprot - Uniprot P01112
Characterization Data
SOPs
No SOPs available.
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