Fas Cell Surface Death Receptor Peptide 1


Background

Catalog Number:

CPTC-FAS-1

RRID:

AB_2889962

Target Antigen:

Fas Cell Surface Death Receptor Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

07/28/2021

Antigen Recognition(s):

Peptide

Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (430.9 KB)

CPTC-FAS-1 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


  NCI 60 Protein Array

CTPC-FAS-1 NCI60 Protein Array

Result: Negative

This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.


  Western Blot - Recombinant Protein or Peptide

CPTC-FAS-1 Western Blot (recombinant protein)

Result: Negative

Western blot using CPTC-FAS-1 as primary antibody against human Fas (TNF receptor superfamily, member 6) (FAS), transcript variant 1, recombinant protein (lane 2). Expected molecular weight - 17.6 kDa.
Molecular weight standards are also included (lane 1).


Characterization SOP Files

Background

NCI Identification Number:

00365

Antigen Name:

Fas Cell Surface Death Receptor Peptide 1

CPTC Name:

CPTC-FAS Peptide 1

Keywords:

Fas Cell Surface Death Receptor; Tumor Necrosis Factor Receptor Superfamily, Member 6; Fas (TNF Receptor Superfamily, Member 6); Apoptosis-Mediating Surface Antigen FAS; TNF Receptor Superfamily Member 6; FASLG Receptor; CD95 Antigen; TNFRSF6; APO-1; APT1; CD95; FAS1; Mutant Tumor Necrosis Receptor Superfamily Member 6; Apoptosis Signaling Receptor FAS; APO-1 Cell Surface Antigen; Apoptosis Antigen 1; Apo-1 Antigen; Fas AMA; ALPS1A; FASTM; FAS

Function:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.FAS (Fas Cell Surface Death Receptor) is a Protein Coding gene. Diseases associated with FAS include Autoimmune Lymphoproliferative Syndrome and Lymphoproliferative Syndrome. Among its related pathways are Apoptosis Modulation and Signaling and Signal transduction_JNK pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is TNFRSF10B.Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Chromosomal Localization:

10q23.31

NCBI Accession Number:

NP_000034.1

UniProt Accession Number:

P25445

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

EA(pY)DTLIK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

880

Last Updated:

09/02/2020

Links

Characterization Data

SOPs

No SOPs available.

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