CD38 Molecule Peptide 1


Background

Catalog Number:

CPTC-CD38-1

Target Antigen:

CD38 Molecule Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

12/15/2020

Antigen Recognition(s):

Peptide

Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (382.1 KB)

CPTC-CD38-1 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


  Western Blot - Recombinant Protein or Peptide

CPTC-CD38-1 Western Blot (recombinant protein)

Result: Negative

Western blot using CPTC-CD38-1 as primary antibody against human CD38 recombinant protein (lane 2). Expected molecular weight - 31.2 kDa. Molecular weight standards are also included (lane 1).


Characterization SOP Files

Background

NCI Identification Number:

00353

Antigen Name:

CD38 Molecule Peptide 1

CPTC Name:

CPTC-CD38 Peptide 1

Keywords:

CD38 Molecule; ADP-Ribosyl Cyclase 1; ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1; 2'-Phospho-Cyclic-ADP-Ribose Transferase; 2'-Phospho-ADP-Ribosyl Cyclase; Cyclic ADP-Ribose Hydrolase 1; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2'-Phospho-ADP-Ribosyl Cyclase/2'-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase; Cluster Of Differentiation 38; CADPr Hydrolase 1; CD38 Antigen; EC 2.4.99.20; EC 3.2.2.6; ADPRC1; CD38; T10

Function:

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. CD38 (CD38 Molecule) is a Protein Coding gene. Diseases associated with CD38 include Richter's Syndrome and Prolymphocytic Leukemia. Among its related pathways are Calcium signaling pathway and Cell-type Dependent Selectivity of CCK2R Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity and hydrolase activity, acting on glycosyl bonds. An important paralog of this gene is BST1.Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Chromosomal Localization:

4p15.32

NCBI Accession Number:

NP_001766.2

UniProt Accession Number:

P28907

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

VQTLEAWVIHGGR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1430

Last Updated:

09/02/2020

Links

Characterization Data

SOPs

No SOPs available.

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