Background
Catalog Number:
CPTC-CD38-1
RRID:
AB_2889955
Target Antigen:
CD38 Molecule Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
02/02/2024
Antigen Recognition(s):
Peptide
Purchase
- DSHB CPTC-CD38-1
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (382.1 KB)
CPTC-CD38-1 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
NCI 60 Protein Array
CTPC-CD38-1 NCI60 Protein Array
Result: Negative
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Characterization SOP Files
Western Blot - Recombinant Protein or Peptide
CPTC-CD38-1 Western Blot (recombinant protein)
Result: Negative
Western blot using CPTC-CD38-1 as primary antibody against human CD38 recombinant protein (lane 2). Expected molecular weight - 31.2 kDa. Molecular weight standards are also included (lane 1).
Characterization SOP Files
Western Blot - Tissue or Cell Lysate
CPTC-CD38-1 Automated Western Blot (Cell Lysate)
Result: Presumed Positive (with additional bands)
Automated western blot using CPTC-CD38-1 as primary antibody against buffy coat (lane 2), HeLa (lane 3), Jurkat (lane 4), A549 (lane 5), MCF7 (lane 6), and H226 (lane 7) whole cell lysates. Expected molecular weight - 34.3 kDa and 13.8 kDa. Molecular weight standards are also included (lane 1). Buffy coat is presumed positive. All other cell lines are negative.
Characterization SOP Files
Background
NCI Identification Number:
00353
Antigen Name:
CD38 Molecule Peptide 1
CPTC Name:
CPTC-CD38 Peptide 1
Aliases:
CD38 Molecule; ADP-Ribosyl Cyclase 1; ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1; 2'-Phospho-Cyclic-ADP-Ribose Transferase; 2'-Phospho-ADP-Ribosyl Cyclase; Cyclic ADP-Ribose Hydrolase 1; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2'-Phospho-ADP-Ribosyl Cyclase/2'-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase; Cluster Of Differentiation 38; CADPr Hydrolase 1; CD38 Antigen; EC 2.4.99.20; EC 3.2.2.6; ADPRC1; CD38; T10
Function:
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. CD38 (CD38 Molecule) is a Protein Coding gene. Diseases associated with CD38 include Richter's Syndrome and Prolymphocytic Leukemia. Among its related pathways are Calcium signaling pathway and Cell-type Dependent Selectivity of CCK2R Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity and hydrolase activity, acting on glycosyl bonds. An important paralog of this gene is BST1.Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Chromosomal Localization:
4p15.32
Accession Number:
NP_001766.2
UniProt Accession Number:
P28907
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
VQTLEAWVIHGGR
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1430
Last Updated:
09/02/2020
Links
- EnsEMBL - EnsEMBL CD38
- Entrez - Entrez CD38
- Uniprot - Uniprot P28907
Characterization Data
SOPs
No SOPs available.
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