TNF Receptor Associated Factor 3


Background

Catalog Number:

CPTC-TRAF3-1

RRID:

AB_2920917

Target Antigen:

TNF Receptor Associated Factor 3

Isotype:

IgG2a

Species:

Mouse Monoclonal Antibody

Last Updated:

09/26/2022

Antigen Recognition(s):

Recombinant Full-length, Endogenous

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Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (314.6 KB)

CPTC-TRAF3-1 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


Background

Catalog Number:

CPTC-TRAF3-2

RRID:

AB_2920918

Target Antigen:

TNF Receptor Associated Factor 3

Isotype:

IgG2a

Species:

Mouse Monoclonal Antibody

Last Updated:

09/28/2022

Antigen Recognition(s):

Recombinant Full-length, Endogenous

Purchase
Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (338.3 KB)

CPTC-TRAF3-2 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


Background

Catalog Number:

CPTC-TRAF3-3

RRID:

AB_2920919

Target Antigen:

TNF Receptor Associated Factor 3

Isotype:

IgG2a

Species:

Mouse Monoclonal Antibody

Last Updated:

02/09/2024

Antigen Recognition(s):

Recombinant Full-length, Endogenous

Purchase
Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (342.8 KB)

CPTC-TRAF3-3 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


Background

NCI Identification Number:

00500

Antigen Name:

TNF Receptor Associated Factor 3

CPTC Name:

CPTC-TRAF3

Aliases:

TNF Receptor Associated Factor 3; CAP-1; CRAF1; LAP1; RING-Type E3 Ubiquitin Transferase TRAF3; TNF Receptor-Associated Factor 3; LMP1-Associated Protein 1; CD40bp; RNF118; CAP1; CD40 Receptor Associated Factor 1; CD40 Receptor-Associated Factor 1; CD40 Associated Protein 1; CD40 Binding Protein; CD40-Binding Protein; EC 2.3.2.27; CD40BP; IIAE5; TRAF3

Function:

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5.TRAF3 (TNF Receptor Associated Factor 3) is a Protein Coding gene. Diseases associated with TRAF3 include Encephalopathy, Acute, Infection-Induced 5 and Herpes Simplex Encephalitis. Among its related pathways are Apoptosis Modulation and Signaling and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein kinase binding and ubiquitin-protein transferase activity. An important paralog of this gene is TRAF5.Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.

Chromosomal Localization:

14q32.32

Expression System:

E.coli

Accession Number:

NP_003291.2

UniProt Accession Number:

Q13114

DNA Source:

N/A

Immunogen:

Native Protein

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

first 254 amino acids of mouse TRAF3 - GSHMASMESSK
KMDAAGTLQPNPPLKLQPDRGAGSVLVPEQGGYKEKFVKTVEDKYKCEKC
RLVLCNPKQTECGHRFCESCMAALLSSSSPKCTACQESIIKDKVFKDNCC
KREILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRADCKEK
VLRKDLRDHVEKACKYREA TCSHCKSQVPMIKLQKHEDTDCPCVVVSCP
HKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASS

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

28000

Last Updated:

07/15/2021

Links

Characterization Data

SOPs

No SOPs available.

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