TNF Receptor Associated Factor 3

CPTC-TRAF3-1

AB_2920917

TNF Receptor Associated Factor 3

IgG2a

Mouse Monoclonal Antibody

09/26/2022

Recombinant Full-length, Endogenous

CPTC-TRAF3-2

AB_2920918

TNF Receptor Associated Factor 3

IgG2a

Mouse Monoclonal Antibody

09/28/2022

Recombinant Full-length, Endogenous

CPTC-TRAF3-3

AB_2920919

TNF Receptor Associated Factor 3

IgG2a

Mouse Monoclonal Antibody

02/09/2024

Recombinant Full-length, Endogenous

00500

TNF Receptor Associated Factor 3

CPTC-TRAF3

TNF Receptor Associated Factor 3; CAP-1; CRAF1; LAP1; RING-Type E3 Ubiquitin Transferase TRAF3; TNF Receptor-Associated Factor 3; LMP1-Associated Protein 1; CD40bp; RNF118; CAP1; CD40 Receptor Associated Factor 1; CD40 Receptor-Associated Factor 1; CD40 Associated Protein 1; CD40 Binding Protein; CD40-Binding Protein; EC 2.3.2.27; CD40BP; IIAE5; TRAF3

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5.TRAF3 (TNF Receptor Associated Factor 3) is a Protein Coding gene. Diseases associated with TRAF3 include Encephalopathy, Acute, Infection-Induced 5 and Herpes Simplex Encephalitis. Among its related pathways are Apoptosis Modulation and Signaling and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein kinase binding and ubiquitin-protein transferase activity. An important paralog of this gene is TRAF5.Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.

14q32.32

E.coli

NP_003291.2

Q13114

N/A

Native Protein

N/A

28000

07/15/2021