Background
Catalog Number:
CPTC-TNNT2-1
Target Antigen:
Troponin T2, Cardiac Type Peptide 1
Isotype:
IgG
Species:
Rabbit Recombinant Cloned Antibody
Last Updated:
08/24/2022
Antigen Recognition(s):
Peptide
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (300.9 KB)
CPTC-TNNT2-1 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
Immuno-MRM
CPTC-TNNT2-1 iMRM
Result: Positive
iMRM data obtained using antibody CPTC-TNNT2-1 to immuno-precipitate peptide 1
Data provided by the Carr Lab, Broad Institute
https://www.broadinstitute.org/proteomics/protocols
Characterization SOP Files
Western Blot - Recombinant Protein or Peptide
CPTC-TNNT2-1 Recombinant Protein WB
Result: Negative
Automated Western Blot with recombinant TNNT2 protein
Characterization SOP Files
Background
NCI Identification Number:
00335
Antigen Name:
Troponin T2, Cardiac Type Peptide 1
CPTC Name:
CPTC-TNNT2 Peptide 1
Aliases:
Troponin T2, Cardiac Type; Cardiomyopathy, Dilated 1D (Autosomal Dominant); Cardiomyopathy, Hypertrophic 2; Troponin T Type 2 (Cardiac); Troponin T, Cardiac Muscle; CMPD2; CTnT; Truncated Cardiac Troponin T; Cardiac Muscle Troponin T; CMD1D; LVNC6; TNNT2; CMH2; RCM3; TnTC; TnTc
Function:
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.TNNT2 (Troponin T2, Cardiac Type) is a Protein Coding gene. Diseases associated with TNNT2 include Cardiomyopathy, Dilated, 1D and Cardiomyopathy, Familial Hypertrophic, 2. Among its related pathways are Dilated cardiomyopathy (DCM) and Mesenchymal Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is TNNT1.Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNT2_HUMAN,P45379
Chromosomal Localization:
1q32.1
Accession Number:
XP_024305218.1
UniProt Accession Number:
P45379
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
VLAIDHLNEDQLR
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1430
Last Updated:
08/23/2020
Links
- EnsEMBL - EnsEMBL TNNT2
- Entrez - Entrez TNNT2
- Uniprot - Uniprot P45379
Characterization Data
SOPs
No SOPs available.
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