Troponin I3, Cardiac Type Peptide 1


Background

Catalog Number:

CPTC-TNNI3-1

Target Antigen:

Troponin I3, Cardiac Type Peptide 1

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

12/21/2020

Antigen Recognition(s):

Peptide

Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image iMRM data obtained using antibody CPTC-TNNI3-1 to immuno-precipitate peptide NITEIADLTQK (CPTC-TNNI3 Peptide 1) Click image to enlarge

CPTC-TNNI3-1 iMRM

Result: Positive

iMRM data obtained using antibody CPTC-TNNI3-1 to immuno-precipitate peptide NITEIADLTQK (CPTC-TNNI3 Peptide 1)


  Western Blot - Recombinant Protein or Peptide

CPTC-TNNI3-1 Recombinant Protein WB

Result: Negative

Automated Western Blot with recombinant TNNI3 protein


Background

NCI Identification Number:

00336

Antigen Name:

Troponin I3, Cardiac Type Peptide 1

CPTC Name:

CPTC-TNNI3 Peptide 1

Keywords:

Troponin I3, Cardiac Type; TNNC1; Cardiomyopathy, Dilated 2A (Autosomal Recessive); Troponin I, Cardiac Muscle; CMH7; Cardiac Troponin I; Troponin I Type 3; CMD1FF; CMD2A; TNNI3; RCM1; CTnI

Function:

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).TNNI3 (Troponin I3, Cardiac Type) is a Protein Coding gene. Diseases associated with TNNI3 include Cardiomyopathy, Dilated, 2A and Cardiomyopathy, Familial Hypertrophic, 7. Among its related pathways are Signal transduction_PKA signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is TNNI1.Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Chromosomal Localization:

19q13.42

NCBI Accession Number:

NP_000354.4

UniProt Accession Number:

P19429

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

NITEIADLTQK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1210

Last Updated:

08/23/2020

Links

Characterization Data

SOPs

No SOPs available.

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