Background
Catalog Number:
CPTC-TNFSF9-1
Target Antigen:
TNF Superfamily Member 9 Peptide 1
Isotype:
IgG1
Species:
Mouse Monoclonal Antibody
Last Updated:
02/09/2024
Antigen Recognition(s):
Peptide
Thematic Panel(s):
Immuno-Oncology (IO)
External Links
- CPTAC Assay Portal CPTAC-5963
Purchase
- DSHB CPTC-TNFSF9-1
Publications
Characterization Data [Compare Characterization Data]
Western Blot - Recombinant Protein or Peptide
CPTC-TNFSF9-1 Western Blot Recombinant Protein
Result: Negative
Western blot using CPTC-TNFSF9-1 as primary antibody against human tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9) recombinant protein (lane 2). Expected molecular weight - 26.4 kDa. Molecular weight standards are also included (lane 1).
Characterization SOP Files
Western Blot - Tissue or Cell Lysate
CPTC-TNFSF9-1 Automated Western Blot Cell Lysate
Result: Negative
Automated western blot using CPTC-TNFSF9-1 as primary antibody against A549 (lane 2), HeLa (lane 3), Jurkat (lane 4), MCF7 (lane 5), H226 (lane 6), and PBMC (lane 7) whole cell lysates. Expected molecular weight - 26.6 kDa. Molecular weight standards are also included (lane 1).
Characterization SOP Files
Background
Catalog Number:
CPTC-TNFSF9-2
Target Antigen:
TNF Superfamily Member 9 Peptide 1
Isotype:
IgG1
Species:
Mouse Monoclonal Antibody
Last Updated:
02/09/2024
Antigen Recognition(s):
Peptide
Purchase
- DSHB CPTC-TNFSF9-2
Characterization Data [Compare Characterization Data]
Background
NCI Identification Number:
00483
Antigen Name:
TNF Superfamily Member 9 Peptide 1
CPTC Name:
CPTC-TNFSF9 Peptide 1
Aliases:
TNFSF9; TNF Superfamily Member 9; 4-1BBL; Tumor Necrosis Factor (Ligand) Superfamily, Member 9; Tumor Necrosis Factor Ligand Superfamily Member 9; Homolog Of Mouse 4-1BB-L; Receptor 4-1BB Ligand; 4-1BB Ligand; 4-1BB-L; Tumor Necrosis Factor Superfamily Member 9; Tumor Necrosis Factor Ligand 5A; CD137L; TNLG5A
Function:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.TNFSF9 (TNF Superfamily Member 9) is a Protein Coding gene. Diseases associated with TNFSF9 include Immunodeficiency 16 and Mouth Disease. Among its related pathways are ERK Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and tumor necrosis factor receptor binding.Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Chromosomal Localization:
19p13.3
Accession Number:
NP_003802.1
UniProt Accession Number:
P41273
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
EGPELSPDDPAGLLDLR
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1870
Last Updated:
03/24/2021
Links
- EnsEMBL - EnsEMBL TNFSF9
- Entrez - Entrez TNFSF9
- Uniprot - Uniprot P41273
Characterization Data
SOPs
No SOPs available.
Don't have Adobe Reader™?
Get it for free at Adobe.com