Background
Catalog Number:
CPTC-TIPRL-1
Target Antigen:
TOR Signaling Pathway Regulator Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
02/24/2025
Antigen Recognition(s):
Peptide, Recombinant Full-length
Purchase
- DSHB CPTC-TIPRL-1
Characterization Data [Compare Characterization Data]
Flow Cytometry
CPTC-TIPRL-1 (Flow Cytometry)
Result: Negative
Flow cytometric analysis of TIP41-like protein expression using CPTC-TIPRL-1 rabbit antibody. U251 cells were fixed, permeabilized, and then stained with CPTC-TIPRL-1 (solid green) or concentration-matched rabbit isotype control (dashed green) antibodies. HT29 cells were fixed, permeabilized, and then stained with CPTC-TIPRL-1 (solid blue) or concentration-matched rabbit isotype control (dashed blue) antibodies. A BV421 conjugated goat anti-rabbit IgG was used as a secondary antibody. All data were analyzed using FlowJo.
Characterization SOP Files
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (294.5 KB)
CPTC-TIPRL-1 Evaluation by the Human Protein Atlas
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
Background
NCI Identification Number:
00444
Antigen Name:
TOR Signaling Pathway Regulator Peptide 1
CPTC Name:
CPTC-TIPRL Peptide 1
Aliases:
TOR Signaling Pathway Regulator; Putative MAPK-Activating Protein PM10; Type 2A-Interacting Protein; TIP41-Like Protein; TIPRL1; TIP41; TIP; TIP41, TOR Signaling Pathway Regulator-Like (S. Cerevisiae); TIP41, TOR Signaling Pathway Regulator-Like; DJ69E11.3; MGC3794; TIPRL
Function:
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) TIPRL (TOR Signaling Pathway Regulator) is a Protein Coding gene. Diseases associated with TIPRL include Alzheimer Disease 15 and Cardiomyopathy, Dilated, 1E.May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Chromosomal Localization:
1q24.2
Accession Number:
NP_690866.1
UniProt Accession Number:
O75663
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
VVPTTDHIDTEK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1320
Last Updated:
09/30/2020
Links
- EnsEMBL - EnsEMBL TIPRL
- Entrez - Entrez TIPRL
- Uniprot - Uniprot O75663
Characterization Data
SOPs
No SOPs available.
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