Sialic Acid Binding Ig Like Lectin 1 Peptide 1


Background

Catalog Number:

CPTC-SIGLEC1-1

Target Antigen:

Sialic Acid Binding Ig Like Lectin 1 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

10/06/2021

Antigen Recognition(s):

Peptide, Recombinant Full-length

Characterization Data [Compare Characterization Data]
  NCI 60 Protein Array

CTPC-SIGLEC1-1 NCI60 Protein Array

Result: Negative

This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.


Background

NCI Identification Number:

00392

Antigen Name:

Sialic Acid Binding Ig Like Lectin 1 Peptide 1

CPTC Name:

CPTC-SIGLEC1 Peptide 1

Keywords:

Sialic Acid Binding Ig Like Lectin 1; Sialoadhesin; Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin; SIGLEC-1; CD169; SN; Sialic Acid-Binding Immunoglobulin-Like Lectin 1; Sialic Acid-Binding Ig-Like Lectin 1; CD169 Antigen; DJ1009E24.1; FLJ00051; FLJ00055; FLJ00073; FLJ32150; Siglec-1; SIGLEC1

Function:

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined.SIGLEC1 (Sialic Acid Binding Ig Like Lectin 1) is a Protein Coding gene. Diseases associated with SIGLEC1 include Proliferative Glomerulonephritis and Diffuse Cutaneous Systemic Sclerosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CD22.Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.

Chromosomal Localization:

20p13

NCBI Accession Number:

NP_075556.1

UniProt Accession Number:

Q9BZZ2

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

LHAEPVPTLAFTHVAR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1760

Last Updated:

09/02/2020

Links

Characterization Data

SOPs

No SOPs available.

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