Regulatory Associated Protein Of MTOR Complex 1 Peptide 3


Background

Catalog Number:

CPTC-RPTOR-2

Target Antigen:

Regulatory Associated Protein Of MTOR Complex 1 Peptide 3

Isotype:

IgG1

Species:

Mouse Monoclonal Antibody

Last Updated:

08/22/2016

Antigen Recognition(s):

peptide

Characterization Data [Compare Characterization Data]
  IPMS

CPTC-RPTOR-2 iMRM

Immuno-MRM chromatogram of CPTC-RPTOR-2 antibody with CPTC-RPTOR peptide 3 (NCI ID#137) as target

Background

NCI Identification Number:

00137

Antigen Name:

Regulatory Associated Protein Of MTOR Complex 1 Peptide 3

CPTC Name:

CPTC-RPTOR Peptide 3

Keywords:

Regulatory Associated Protein Of MTOR Complex 1; Regulatory Associated Protein Of MTOR, Complex 1; Raptor; P150 Target Of Rapamycin (TOR)-Scaffold Protein Containing WD-Repeats; P150 Target Of Rapamycin (TOR)-Scaffold Protein; Regulatory Associated Protein Of MTOR; KIAA1303; MIP1; KOG1

Function:

This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.

RPTOR (Regulatory Associated Protein Of MTOR Complex 1) is a Protein Coding gene. Diseases associated with RPTOR include aqueous misdirection and moyamoya disease. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include binding and protein complex binding.

Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at Thr-389, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.

Chromosomal Localization:

17q25.3

Expression System:

NCBI Accession Number:

NP_001156506.1

Swiss Prot Accession Number:

Q8N122

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

ALETIGANLQK

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1210

Last Updated:

07/12/2016

Links

Characterization Data

SOPs

No SOPs available.

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