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Programmed Cell Death 1 Peptide 1

Antibody: CPTC-PDCD1-1
Background

Catalog Number:

CPTC-PDCD1-1

Target Antigen:

Programmed Cell Death 1 Peptide 1

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

02/09/2024

Antigen Recognition(s):

Peptide

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Characterization Data [Compare Characterization Data]
  Western Blot - Recombinant Protein or Peptide

CPTC-PDCD1-1 Western Blot Recombinant Protein

Result: Negative

Western blot using CPTC-PDCD1-1 as primary antibody against human programmed cell death 1 (PDCD1) recombinant protein (lane 2). Expected molecular weight - 29.2 kDa. Molecular weight standards are also included (lane 1).


Characterization SOP Files

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Antigen: Programmed Cell Death 1 Peptide 1
Background

NCI Identification Number:

00498

Antigen Name:

Programmed Cell Death 1 Peptide 1

CPTC Name:

CPTC-PDCD1 Peptide 1

Aliases:

Programmed Cell Death 1; PD1; Systemic Lupus Erythematosus Susceptibility 2; Programmed Cell Death Protein 1; Protein PD-1; CD279; HPD-1; HSLE1; PD-1; Programmed Cell Death 1 Protein; CD279 Antigen; SLEB2; HPD-L; PDCD1

Function:

Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.PDCD1 (Programmed Cell Death 1) is a Protein Coding gene. Diseases associated with PDCD1 include Systemic Lupus Erythematosus 2 and Multiple Sclerosis. Among its related pathways are IgA-Producing B Cells in the Intestine and Translocation of ZAP-70 to Immunological synapse. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity.Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self (PubMed:21276005). Delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2 (PubMed:21276005). Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2 that mediates dephosphorylation of key TCR proximal signaling molecules, such as ZAP70, PRKCQ/PKCtheta and CD247/CD3zeta (By similarity).The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed:28951311). The interaction with CD274/PDCD1L1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed:28951311). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed:22658127, PubMed:25034862, PubMed:25399552).

Chromosomal Localization:

2q37.3

Accession Number:

NP_005009.2

UniProt Accession Number:

Q15116

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

LAAFPEDR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

880

Last Updated:

07/15/2021

Links

Characterization Data

SOPs

No SOPs available.

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