Nuclear Mitotic Apparatus Protein 1 Peptide 1


Background

Catalog Number:

CPTC-NUMA1-1

Target Antigen:

Nuclear Mitotic Apparatus Protein 1 Peptide 1

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

02/19/2020

Antigen Recognition(s):

Peptide, Phosphorylation

Background

NCI Identification Number:

00291

Antigen Name:

Nuclear Mitotic Apparatus Protein 1 Peptide 1

CPTC Name:

CPTC-NUMA1 Peptide 1

Keywords:

Nuclear Mitotic Apparatus Protein 1; Nuclear Matrix Protein-22; SP-H Antigen; NMP-22; NUMA; Nuclear Mitotic Apparatus Protein; Structural Nuclear Protein; NuMA Protein; NMP22

Function:

This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants.NUMA1 (Nuclear Mitotic Apparatus Protein 1) is a Protein Coding gene. Diseases associated with NUMA1 include Acute Promyelocytic Leukemia and Pyuria. Among its related pathways are Apoptosis and survival Caspase cascade and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include nucleotide binding and microtubule binding. An important paralog of this gene is GOLGA3.Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity).

Chromosomal Localization:

11q13.4

NCBI Accession Number:

na

UniProt Accession Number:

Q14980

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

CLSQLEEHLS(ph)QLQDNPPQEK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

2200

Last Updated:

10/22/2019

Links

Characterization Data

SOPs

No SOPs available.

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