MutS Homolog 3 Peptide 1


Background

Catalog Number:

CPTC-MSH3-1

Target Antigen:

MutS Homolog 3 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

02/09/2024

Antigen Recognition(s):

Peptide, Endogenous

Thematic Panel(s):

Immuno-Oncology (IO)

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Characterization Data [Compare Characterization Data]
  IHC HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (487.7 KB)

CPTC-MSH3-1 evaluation by the Human Protein Atlas

Result: Negative

Results provided by the Human Protein Atlas (www.proteinatlas.org).


  Immunofluorescence - HPA
Download Results provided by the Human Protein Atlas (www.proteinatlas.org). (487.7 KB)

CPTC-MSH3-1 evaluation by the Human Protein Atlas

Result: Negative

Results provided by the Human Protein Atlas (www.proteinatlas.org).


Background

NCI Identification Number:

00501

Antigen Name:

MutS Homolog 3 Peptide 1

CPTC Name:

CPTC-MSH3 Peptide 1

Aliases:

MutS Homolog 3; MRP1; DUP; Divergent Upstream Protein; Mismatch Repair Protein 1; DNA Mismatch Repair Protein Msh3; HMSH3; Epididymis Secretory Sperm Binding Protein; MutS (E. Coli) Homolog 3; MutS Homolog 3 (E. Coli); FAP4; DUC1; DUG

Function:

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.MSH3 (MutS Homolog 3) is a Protein Coding gene. Diseases associated with MSH3 include Familial Adenomatous Polyposis 4 and Endometrial Cancer. Among its related pathways are Mismatch repair and Colorectal Cancer Metastasis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and single-stranded DNA binding. An important paralog of this gene is MSH6.Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Chromosomal Localization:

5q14.1

Accession Number:

NP_002430.3

UniProt Accession Number:

P20585

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

DLSDFPLIK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

990

Last Updated:

10/12/2021

Links

Characterization Data

SOPs

No SOPs available.

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