Myeloperoxidase Peptide 1


Background

Catalog Number:

CPTC-MPO-1

RRID:

AB_2814784

Target Antigen:

Myeloperoxidase Peptide 1

Isotype:

IgG

Species:

Mouse Monoclonal Antibody

Last Updated:

06/25/2021

Antigen Recognition(s):

Peptide

Characterization Data [Compare Characterization Data]
Background

Catalog Number:

CPTC-MPO-2

RRID:

AB_2814785

Target Antigen:

Myeloperoxidase Peptide 1

Isotype:

IgG

Species:

Mouse Monoclonal Antibody

Last Updated:

08/31/2022

Antigen Recognition(s):

Peptide, Recombinant Full-length

Characterization Data [Compare Characterization Data]
Background

Catalog Number:

CPTC-MPO-3

Target Antigen:

Myeloperoxidase Peptide 1

Isotype:

IgG

Species:

Mouse Monoclonal Antibody

Last Updated:

10/28/2021

Antigen Recognition(s):

Peptide

Characterization Data [Compare Characterization Data]
Background

NCI Identification Number:

00478

Antigen Name:

Myeloperoxidase Peptide 1

CPTC Name:

CPTC-MPO Peptide 1

Aliases:

Myeloperoxidase; EC 1.11.1.7; EC 1.11.2.2; EC 1.11.1; MPO

Function:

Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils.MPO (Myeloperoxidase) is a Protein Coding gene. Diseases associated with MPO include Myeloperoxidase Deficiency and Alzheimer Disease. Among its related pathways are Transcriptional misregulation in cancer and Folate Metabolism. Gene Ontology (GO) annotations related to this gene include chromatin binding and heme binding. An important paralog of this gene is EPX.Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Chromosomal Localization:

17q22

Accession Number:

NP_000241.1

UniProt Accession Number:

P05164

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

IGLDLPALNMQR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1320

Last Updated:

12/17/2020

Links

Characterization Data

SOPs

No SOPs available.

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