DNA Ligase 1 Peptide 1


Background

Catalog Number:

CPTC-LIG1-1

Target Antigen:

DNA Ligase 1 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

02/06/2024

Antigen Recognition(s):

Peptide, Recombinant Full-length, Endogenous

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Characterization Data [Compare Characterization Data]
Background

NCI Identification Number:

00377

Antigen Name:

DNA Ligase 1 Peptide 1

CPTC Name:

CPTC-LIG1 Peptide 1

Aliases:

DNA Ligase 1; Polydeoxyribonucleotide Synthase [ATP] 1; Ligase I, DNA, ATP-Dependent; EC 6.5.1.1; DNA Ligase I; LIG1

Function:

This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.LIG1 (DNA Ligase 1) is a Protein Coding gene. Diseases associated with LIG1 include Bloom Syndrome and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include DNA ligase activity and DNA ligase (ATP) activity. An important paralog of this gene is LIG3.DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Ligases are enzymes which catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. They belong to the E.C. 6 class of enzymes, which also includes synthases and carboxylases.

Chromosomal Localization:

19q13.33

Accession Number:

NP_000225.1

UniProt Accession Number:

P18858

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

AQIHALEGGEVK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1320

Last Updated:

09/02/2020

Links

Characterization Data

SOPs

No SOPs available.

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