Catalog Number:
CPTC-LIG1-1
Target Antigen:
DNA Ligase 1 Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
02/06/2024
Antigen Recognition(s):
Peptide, Recombinant Full-length, Endogenous
NCI Identification Number:
00377
Antigen Name:
DNA Ligase 1 Peptide 1
CPTC Name:
CPTC-LIG1 Peptide 1
Aliases:
DNA Ligase 1; Polydeoxyribonucleotide Synthase [ATP] 1; Ligase I, DNA, ATP-Dependent; EC 6.5.1.1; DNA Ligase I; LIG1
Function:
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.LIG1 (DNA Ligase 1) is a Protein Coding gene. Diseases associated with LIG1 include Bloom Syndrome and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include DNA ligase activity and DNA ligase (ATP) activity. An important paralog of this gene is LIG3.DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Ligases are enzymes which catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. They belong to the E.C. 6 class of enzymes, which also includes synthases and carboxylases.
Chromosomal Localization:
19q13.33
Accession Number:
NP_000225.1
UniProt Accession Number:
P18858
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
AQIHALEGGEVK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1320
Last Updated:
09/02/2020
No SOPs available.
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