Linker For Activation Of T Cells Peptide 1


Background

Catalog Number:

CPTC-LAT-1

Target Antigen:

Linker For Activation Of T Cells Peptide 1

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

06/19/2020

Antigen Recognition(s):

Peptide, Phosphorylation

Characterization Data [Compare Characterization Data]
Background

NCI Identification Number:

00300

Antigen Name:

Linker For Activation Of T Cells Peptide 1

CPTC Name:

CPTC-LAT Peptide 1

Keywords:

Linker For Activation Of T Cells; Linker For Activation Of T Cells, Transmembrane Adaptor; Linker For Activation Of T-Cells Family Member 1; 36 KDa Phospho-Tyrosine Adapter Protein; P36-38; Pp36; 36 KDa Phospho-Tyrosine Adaptor Protein; IMD52; LAT1

Function:

he protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. LAT (Linker For Activation Of T Cells) is a Protein Coding gene. Diseases associated with LAT include Immunodeficiency 52 and Cranial Nerve Palsy. Among its related pathways are RET signaling and G beta-gamma signalling through PI3Kgamma. Gene Ontology (GO) annotations related to this gene include protein kinase binding and SH3/SH2 adaptor activity.Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Chromosomal Localization:

16p11.2

NCBI Accession Number:

na

UniProt Accession Number:

O43561

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

CEYVNVS(ph)QELHPGAAK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1760

Last Updated:

10/22/2019

Links

Characterization Data

SOPs

No SOPs available.

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