Keratin 5 Peptide 2


Background

Catalog Number:

CPTC-KRT5-2

Target Antigen:

Keratin 5 Peptide 2

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

01/25/2019

Antigen Recognition(s):

Peptide

SOP:

Characterization Data [Compare Characterization Data]
  Immuno-MRM

CPTC-KRT5-2 iMRM

Immuno-MRM chromatogram of CPTC-KRT5-2 antibody with CPTC-KRT5 peptide 1 (NCI ID#00242) as target

Background

NCI Identification Number:

00242

Antigen Name:

Keratin 5 Peptide 2

CPTC Name:

CPTC-KRT5 Peptide 2

Keywords:

Keratin 5; Keratin 5 (Epidermolysis Bullosa Simplex, Dowling-Meara/Kobner/Weber-Cockayne Types); Epidermolysis Bullosa Simplex 2 Dowling-Meara/Kobner/Weber-Cockayne Types; Type-II Keratin Kb5; Keratin 5, Type II; Cytokeratin-5; CK-5; K5; Keratin, Type II Cytoskeletal 5; 58 Kda Cytokeratin; 58 KDa Cytokeratin; Keratin-5; KRT5A; DDD1; EBS2; CK5; DDD

Function:

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

KRT5 (Keratin 5) is a Protein Coding gene. Diseases associated with KRT5 include Epidermolysis Bullosa Simplex, Dowling-Meara Type and Epidermolysis Bullosa Simplex, Weber-Cockayne Type. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Keratinization. GO annotations related to this gene include structural molecule activity and scaffold protein binding. An important paralog of this gene is KRT6C.

Chromosomal Localization:

12q13.13

NCBI Accession Number:

NP_000415.2

Swiss Prot Accession Number:

P13647

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

SFSTASAITPSVSR

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1540

Last Updated:

02/26/2018

Links

Characterization Data

SOPs

No SOPs available.

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