Catalog Number:
CPTC-KRT5-1
RRID:
AB_2820262
Target Antigen:
Keratin 5 Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
09/01/2022
Antigen Recognition(s):
Peptide
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Result: Positive
Immuno-MRM chromatogram of CPTC-KRT5-1 antibody with CPTC-KRT5 peptide 1 (NCI ID#00241) as target
Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html)
Result: Negative
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
NCI Identification Number:
00241
Antigen Name:
Keratin 5 Peptide 1
CPTC Name:
CPTC-KRT5 Peptide 1
Aliases:
Keratin 5; Keratin 5 (Epidermolysis Bullosa Simplex, Dowling-Meara/Kobner/Weber-Cockayne Types); Epidermolysis Bullosa Simplex 2 Dowling-Meara/Kobner/Weber-Cockayne Types; Type-II Keratin Kb5; Keratin 5, Type II; Cytokeratin-5; CK-5; K5; Keratin, Type II Cytoskeletal 5; 58 Kda Cytokeratin; 58 KDa Cytokeratin; Keratin-5; KRT5A; DDD1; EBS2; CK5; DDD
Function:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
KRT5 (Keratin 5) is a Protein Coding gene. Diseases associated with KRT5 include Epidermolysis Bullosa Simplex, Dowling-Meara Type and Epidermolysis Bullosa Simplex, Weber-Cockayne Type. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Keratinization. GO annotations related to this gene include structural molecule activity and scaffold protein binding. An important paralog of this gene is KRT6C.
Chromosomal Localization:
12q13.13
Accession Number:
NP_000415.2
UniProt Accession Number:
P13647
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
AQYEEIANR
Native Sequence:
Calculated Isoelectric Point:
0
Molecular Weight:
990
Last Updated:
02/26/2018
No SOPs available.
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