Background
Catalog Number:
CPTC-JAK1-1
Target Antigen:
Janus Kinase 1 Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
07/11/2022
Antigen Recognition(s):
Peptide, Recombinant Full-length
Purchase
- DSHB CPTC-JAK1-1
Characterization Data [Compare Characterization Data]
Background
NCI Identification Number:
00376
Antigen Name:
Janus Kinase 1 Peptide 1
CPTC Name:
CPTC-JAK1 Peptide 1
Aliases:
Janus Kinase 1; JAK1A; Tyrosine-Protein Kinase JAK1; EC 2.7.10.2; JAK1B; JTK3; EC 2.7.10; JAK-1; JAK1
Function:
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants.AK1 (Janus Kinase 1) is a Protein Coding gene. Diseases associated with JAK1 include Breast Implant-Associated Anaplastic Large Cell Lymphoma and Polycythemia Vera. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and RET signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TYK2.Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).
Chromosomal Localization:
1p31.3
Accession Number:
NP_001307852.1
UniProt Accession Number:
P23458
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
LSDPGIPITVLSR
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1430
Last Updated:
09/02/2020
Links
- EnsEMBL - EnsEMBL JAK1
- Entrez - Entrez JAK1
- Uniprot - Uniprot P23458
Characterization Data
SOPs
No SOPs available.
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