Background
Catalog Number:
CPTC-GZMA-1
RRID:
AB_2890081
Target Antigen:
Granzyme A Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
02/06/2024
Antigen Recognition(s):
Peptide, Recombinant Full-length, Endogenous
Purchase
- DSHB CPTC-GZMA-1
Characterization Data [Compare Characterization Data]
NCI 60 Protein Array
CTPC-GZMA-1 NCI60 Protein Array
Result: Negative
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
Characterization SOP Files
Background
NCI Identification Number:
00366
Antigen Name:
Granzyme A Peptide 1
CPTC Name:
CPTC-GZMA Peptide 1
Aliases:
Granzyme A; CTL Tryptase; Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated Serine Esterase 3); Cytotoxic T-Lymphocyte-Associated Serine Esterase-3; Cytotoxic T-Lymphocyte Proteinase 1; Hanukah Factor Serine Protease; Fragmentin-1; Granzyme 1; H Factor; CTLA3; HFSP; HF; Granzyme A (Cytotoxic T-Lymphocyte-Associated Serine Esterase-3; Hanukah Factor Serine Protease); Hanukkah Factor; EC 3.4.21; EC 3.4.21.78; Granzyme-1; GZMA
Function:
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells.GZMA (Granzyme A) is a Protein Coding gene. Diseases associated with GZMA include Chediak-Higashi Syndrome and Smallpox. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Granzyme-A Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and serine-type peptidase activity. An important paralog of this gene is GZMK.Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
Chromosomal Localization:
5q11.2
Accession Number:
NP_006135.2
UniProt Accession Number:
P12544
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
EFPYPCYDPATR
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1320
Last Updated:
09/02/2020
Links
- EnsEMBL - EnsEMBL GZMA
- Entrez - Entrez GZMA
- Uniprot - Uniprot P12544
Characterization Data
SOPs
No SOPs available.
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