C-X-C Motif Chemokine Ligand 10 Peptide 2

CPTC-CXCL10-2

AB_2943348

C-X-C Motif Chemokine Ligand 10 Peptide 2

IgG1

Mouse Recombinant Cloned Antibody

12/05/2023

Peptide, Recombinant Full-length

00421

C-X-C Motif Chemokine Ligand 10 Peptide 2

CPTC-CXCL10 Peptide 2

C-X-C Motif Chemokine Ligand 10; IP-10; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10; 10 KDa Interferon Gamma-Induced Protein; Small-Inducible Cytokine B10; C-X-C Motif Chemokine 10; SCYB10; GIP-10; IFI10; INP10; Crg-2; Mob-1; C7; Protein 10 From Interferon (Gamma)-Induced Cell Line; Interferon-Inducible Cytokine IP-10; Chemokine (C-X-C Motif) Ligand 10; Gamma IP10; Gamma-IP10; CXCL10

This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Hepatitis C and Endotheliitis. Among its related pathways are Signaling by GPCR and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and chemokine activity. An important paralog of this gene is CXCL9.Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).

4q21.1

NP_001556.2

P02778

N/A

Synthetic Peptide

N/A

1320

09/20/2020