Colony Stimulating Factor 1 Peptide 1


Background

Catalog Number:

CPTC-CSF1-1

Target Antigen:

Colony Stimulating Factor 1 Peptide 1

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

06/23/2021

Antigen Recognition(s):

Peptide

Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF provides the evaluation results as provided by the Human Protein Atlas (www.proteinatlas.org). (576.0 KB)

CPTC-CSF1-1 evaluation by the Human Protein Atlas

Result: Negative

This PDF provides the evaluation results as provided by the Human Protein Atlas (www.proteinatlas.org).


Background

NCI Identification Number:

00428

Antigen Name:

Colony Stimulating Factor 1 Peptide 1

CPTC Name:

CPTC-CSF1 Peptide 1

Keywords:

Colony Stimulating Factor 1; MCSF; Colony Stimulating Factor 1 (Macrophage); Macrophage Colony Stimulating Factor 1; Macrophage Colony-Stimulating Factor 1; Lanimostim; CSF-1; M-CSF; MGC31930; CSF1

Function:

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants.CSF1 (Colony Stimulating Factor 1) is a Protein Coding gene. Diseases associated with CSF1 include Pigmented Villonodular Synovitis and Tenosynovial Giant Cell Tumor. Among its related pathways are Ras signaling pathway and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and growth factor activity.Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.

Chromosomal Localization:

1p13.3

NCBI Accession Number:

NP_000748.4

UniProt Accession Number:

P09603

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

SHSSGSVLPLGELEGR

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

1760

Last Updated:

09/21/2020

Links

Characterization Data

SOPs

No SOPs available.

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