Cadherin 1 Peptide 5


Background

Catalog Number:

CPTC-CDH1-3

Target Antigen:

Cadherin 1 Peptide 5

Isotype:

IgG1

Species:

Mouse Monoclonal Antibody

Last Updated:

11/14/2019

Antigen Recognition(s):

Peptide, Recombinant Full-length, Native Protein

Thematic Panel(s):

Ras Pathway

SOP:

Purchase
External Links
Characterization Data [Compare Characterization Data]
  IHC Tissue
Click to enlarge image Tissue Microarray core of ovarian cancer showing immunohistochemical staining using antibody CPTC-CDH1-3. Click image to enlarge

CPTC-CDH1-3 IHC

Result: Positive

Tissue Microarray core of ovarian cancer showing immunohistochemical staining using antibody CPTC-CDH1-3.


  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-CDH1-3 antibody with CPTC-CDH1 peptide 5 (NCI ID#171) as target Click image to enlarge

CPTC-CDH1-3 iMRM

Result: Positive

Immuno-MRM chromatogram of CPTC-CDH1-3 antibody with CPTC-CDH1 peptide 5 (NCI ID#171) as target


  Western Blot - Cell Lysate
Click to enlarge image Western Blot using CPTC-CDH1-3 as primary Ab against MCF10A-KRas cell lysate (lane 2). Also included are molecular wt. standards (lane 1). Click image to enlarge

CPTC-CDH1-3 Cell Lysate Western Blot

Result: Positive

Western Blot using CPTC-CDH1-3 as primary Ab against MCF10A-KRas cell lysate (lane 2). Also included are molecular wt. standards (lane 1).


  Western Blot - Recombinant Protein or Peptide
Click to enlarge image Western Blot using CPTC-CDH1-3 as primary Ab against recombinant CDH1 (lane 2). Also included are molecular wt. standards (lane 1). Click image to enlarge

CPTC-CDH1-3 Western Blot

Result: Positive

Western Blot using CPTC-CDH1-3 as primary Ab against recombinant CDH1 (lane 2). Also included are molecular wt. standards (lane 1).


Background

Catalog Number:

CPTC-CDH1-4

Target Antigen:

Cadherin 1 Peptide 5

Isotype:

IgG2c

Species:

Mouse Monoclonal Antibody

Last Updated:

11/14/2019

Antigen Recognition(s):

Peptide, Recombinant Full-length, Native Protein

Thematic Panel(s):

Ras Pathway

SOP:

Purchase
External Links
Characterization Data [Compare Characterization Data]
  IHC Tissue
Click to enlarge image Tissue Microarray cor of breast cancer showing immunohistochemical staining for CPTC-CDH1-4. Click image to enlarge

CPTC-CDH1-4 IHC

Result: Positive

Tissue Microarray cor of breast cancer showing immunohistochemical staining for CPTC-CDH1-4.


  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-CDH1-4 antibody with CPTC-CDH1 peptide 5 (NCI ID#171) as target Click image to enlarge

CPTC-CDH1-4 iMRM

Result: Positive

Immuno-MRM chromatogram of CPTC-CDH1-4 antibody with CPTC-CDH1 peptide 5 (NCI ID#171) as target


  Western Blot - Cell Lysate
Click to enlarge image Western Blot using CPTC-CDH1-4 as primary Ab against MCF10A-KRas cell lysate (lane 2). Also included are molecular wt. standards (lane 1). Click image to enlarge

CPTC-CDH1-4 Cell Lysate Western Blot

Result: Positive

Western Blot using CPTC-CDH1-4 as primary Ab against MCF10A-KRas cell lysate (lane 2). Also included are molecular wt. standards (lane 1).


  Western Blot - Recombinant Protein or Peptide
Click to enlarge image Western Blot using CPTC-CDH1-4 as primary Ab against CDH1 (lane 2). Also included are molecular wt. standards (lane 1). Click image to enlarge

CPTC-CDH1-4 Western Blot

Result: Positive

Western Blot using CPTC-CDH1-4 as primary Ab against CDH1 (lane 2). Also included are molecular wt. standards (lane 1).


Background

NCI Identification Number:

00171

Antigen Name:

Cadherin 1 Peptide 5

CPTC Name:

CPTC-CDH1 Peptide 5

Keywords:

Cadherin 1; E-Cadherin; Cadherin 1, Type 1, E-Cadherin (Epithelial); Epithelial Cadherin; CAM 120/80; Uvomorulin; CDHE; UVO; Calcium-Dependent Adhesion Protein, Epithelial; Cadherin 1, E-Cadherin (Epithelial); Cadherin 1, Type 1; Cell-CAM 120/80; CD324 Antigen; E-Cadherin 1; Cadherin-1; Arc-1; CD324; ECAD; LCAM

Function:

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.

CDH1 (Cadherin 1) is a Protein Coding gene. Diseases associated with CDH1 include Gastric Cancer Risk After H. Pylori Infection and Endometrial Cancer. Among its related pathways are Pathways in cancer and Nectin adhesion pathway. GO annotations related to this gene include calcium ion binding and protein phosphatase binding. An important paralog of this gene is CDH3.

adherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Chromosomal Localization:

16q22.1

NCBI Accession Number:

XP_011521791.1

Swiss Prot Accession Number:

P12830

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

GQVPENEANVVITTLK

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1760

Last Updated:

10/01/2019

Links

Characterization Data

SOPs

No SOPs available.

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