Bruton Tyrosine Kinase Peptide 1
Rabbit Monoclonal Antibody
This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.
NCI Identification Number:
Bruton Tyrosine Kinase Peptide 1
CPTC-BTK Peptide 1
Bruton Tyrosine Kinase; ATK; Bruton Agammaglobulinemia Tyrosine Kinase; Tyrosine-Protein Kinase BTK; Bruton'S Tyrosine Kinase; B-Cell Progenitor Kinase; EC 22.214.171.124; PSCTK1; AGMX1; BPK; XLA; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 13 To 17); Dominant-Negative Kinase-Deficient Brutons Tyrosine Kinase; Tyrosine-Protein Kinase BTK Isoform (Lacking Exon 14); Truncated Bruton Agammaglobulinemia Tyrosine Kinase; Agammaglobulinaemia Tyrosine Kinase; Agammaglobulinemia Tyrosine Kinase; EC 2.7.10; IGHD3; IMD1; BTK; AT
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. BTK (Bruton Tyrosine Kinase) is a Protein Coding gene. Diseases associated with BTK include Agammaglobulinemia, X-Linked and Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia. Among its related pathways are Antigen processing-Cross presentation and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is TEC.Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis. Bruton's Tyrosine Kinase (BTK) is member of the Tec family that is critically important for the growth, differentiation and activation of myeloid-, mast- and B-cells. BTK is initially activated by membrane localization which is stimulated by the generation of PIP3.
UniProt Accession Number:
Calculated Isoelectric Point:
No SOPs available.
Get it for free at Adobe.com