Background
Catalog Number:
CPTC-B2M-1
RRID:
AB_2890076
Target Antigen:
Beta-2-Microglobulin Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
02/02/2024
Antigen Recognition(s):
Peptide
Purchase
- DSHB CPTC-B2M-1
Characterization Data [Compare Characterization Data]
Background
NCI Identification Number:
00346
Antigen Name:
Beta-2-Microglobulin Peptide 1
CPTC Name:
CPTC-B2M Peptide 1
Aliases:
Beta-2-Microglobulin; Beta Chain Of MHC Class I Molecules; Beta-2-Microglobin; IMD43; B2M
Function:
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.B2M (Beta-2-Microglobulin) is a Protein Coding gene. Diseases associated with B2M include Immunodeficiency 43 and Amyloidosis, Familial Visceral. Among its related pathways are Antigen processing-Cross presentation and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is HLA-DPA1.Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Chromosomal Localization:
15q21.1
Accession Number:
NP_004039.1
UniProt Accession Number:
P61769
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
VNHVTLSQPK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1100
Last Updated:
09/02/2020
Links
- EnsEMBL - EnsEMBL B2M
- Entrez - Entrez B2M
- Uniprot - Uniprot P61769
Characterization Data
SOPs
No SOPs available.
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