V-Akt Murine Thymoma Viral Oncogene Homolog 3 Peptide 4


Background

Catalog Number:

CPTC-AKT3-1

Target Antigen:

V-Akt Murine Thymoma Viral Oncogene Homolog 3 Peptide 4

Isotype:

IgG3

Species:

Mouse Monoclonal Antibody

Last Updated:

04/19/2018

Antigen Recognition(s):

peptide

Background

NCI Identification Number:

00158

Antigen Name:

V-Akt Murine Thymoma Viral Oncogene Homolog 3 Peptide 4

CPTC Name:

CPTC-AKT3 Peptide 4

Keywords:

V-Akt Murine Thymoma Viral Oncogene Homolog 3; RAC-PK-Gamma; EC 2.7.11.1; PKB Gamma; STK-2; PKBG; V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma); RAC-Gamma Serine/Threonine Protein Kinase; Protein Kinase B Gamma; Protein Kinase Akt-3; Protein Kinase B; PKB-GAMMA; RAC-Gamma; EC 2.7.11; MPPH2; PRKBG; MPPH

Function:

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.

AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3) is a Protein Coding gene. Diseases associated with AKT3 include megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 and hemimegalencephaly. Among its related pathways are Platelet activation, signaling and aggregation and Gene Expression. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AKT1.

AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane.

Chromosomal Localization:

1q44

Expression System:

NCBI Accession Number:

NP_001193658.1

Swiss Prot Accession Number:

Q9Y243

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

RPHFPQF(pS)YSASGR

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1650

Last Updated:

04/19/2018

Links

Characterization Data

SOPs

No SOPs available.

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