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ATR Interacting Protein Peptide 1

Antibody: CPTC-ATRIP-1
Background

Catalog Number:

CPTC-ATRIP-1

RRID:

AB_2888945

Target Antigen:

ATR Interacting Protein Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

01/04/2023

Antigen Recognition(s):

Peptide, Endogenous, Phosphorylation

Thematic Panel(s):

DNA Damage Response (DDR) Pathway

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Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (375.1 KB)

CPTC-ATRIP-1 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


Characterization SOP Files

  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-ATRIP-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3216) Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html) Click image to enlarge

CPTC-ATRIP-1 iMRM

Result: Positive

Immuno-MRM chromatogram of CPTC-ATRIP-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3216)

Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html)


Characterization SOP Files

  Western Blot - HPA - tissue or cell lysate
Click to enlarge image Results provided by the Human Protein Atlas (www.proteinatlas.org). Single band corresponding to the predicted size in kDa (+/-20%). Analysis performed using a standard panel of samples. Antibody dilution: 1:500 Click image to enlarge

CPTC-ATRIP-1 Evaluation by the Human Protein Atlas

Result: Positive

Results provided by the Human Protein Atlas (www.proteinatlas.org). Single band corresponding to the predicted size in kDa (+/-20%). Analysis performed using a standard panel of samples. Antibody dilution: 1:500


Characterization SOP Files

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Antigen: ATR Interacting Protein Peptide 1
Background

NCI Identification Number:

00192

Antigen Name:

ATR Interacting Protein Peptide 1

CPTC Name:

CPTC-ATRIP Peptide 1

Aliases:

ATR Interacting Protein; ATM And Rad3-Related-Interacting Protein; AGS1

Function:

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.

ATRIP (ATR Interacting Protein) is a Protein Coding gene. Diseases associated with ATRIP include Seckel Syndrome and Seckel Syndrome 8. Among its related pathways are Fanconi anemia pathway and E2F mediated regulation of DNA replication. GO annotations related to this gene include nucleic acid binding and K63-linked polyubiquitin binding.

Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.

Chromosomal Localization:

3p21.31

Accession Number:

NP_001257951.1

UniProt Accession Number:

Q8WXE1

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

LAAPSVSHV(pS)PR (pS224)

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1320

Last Updated:

02/16/2017

Links

Characterization Data

SOPs

No SOPs available.

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