Background
Catalog Number:
CPTC-CDK12-1
RRID:
AB_2943349
Target Antigen:
Cyclin Dependent Kinase 12 Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
07/19/2024
Antigen Recognition(s):
Peptide
Characterization Data [Compare Characterization Data]
Background
NCI Identification Number:
00544
Antigen Name:
Cyclin Dependent Kinase 12 Peptide 1
CPTC Name:
CPTC-CDK12 Peptide 1
Aliases:
Cyclin Dependent Kinase 12; CRK7; Cdc2-Related Kinase, Arginine/Serine-Rich; KIAA0904; CRKRS; CRKR; Cell Division Cycle 2-Related Protein Kinase 7; Cell Division Protein Kinase 12; CDC2-Related Protein Kinase 7; Cyclin-Dependent Kinase 12; EC 2.7.11.22; CDC2 Related Protein Kinase 7; EC 2.7.11.23; EC 2.7.11; HCDK12; CrkRS
Function:
Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. CDK12 (Cyclin Dependent Kinase 12) is a Protein Coding gene. Diseases associated with CDK12 include Lung Cancer Susceptibility 3 and Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder. Among its related pathways are Gene expression (Transcription) and Formation of HIV elongation complex in the absence of HIV Tat. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK13.Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Chromosomal Localization:
17q12
Accession Number:
UniProt Accession Number:
Q9NYV4
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
CNSGPALTESLVQTLVK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1869
Last Updated:
04/20/2023
Links
- EnsEMBL - EnsEMBL CDK12
- Entrez - Entrez CDK12
- Uniprot - Uniprot Q9NYV4
Characterization Data
SOPs
No SOPs available.
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