Background
Catalog Number:
CPTC-WWC2-1
Target Antigen:
WW And C2 Domain Containing 2
Isotype:
IgG2b
Species:
Mouse Monoclonal Antibody
Last Updated:
08/16/2023
Antigen Recognition(s):
Peptide, Recombinant Full-length, Endogenous
Characterization Data [Compare Characterization Data]
Western Blot - Over-expressed transient protein in cell lysate
CPTC-WWC2-1 automated WB (over-expressed lysate)
Result: Positive
Automated Western Blot using antibody CPTC-WWC2-1 as primary antibody. The antibody was tested against overexpressed lysates of WWC1, WWC2 and WWC3. The antibody specifically recognizes the target WWC2.
Characterization SOP Files
Western Blot - Tissue or Cell Lysate
CPTC-WWC2-1 automated WB (lysate)
Result: Positive
Automated Western Blot using antibody CPTC-WWC2-1 as primary antibody. The antibody was tested against cell lysates of SF-539 and HS 578T. The antibody recognized the target protein in both cell lysates. The cell lysates were also tested with anti-Cytochrome C antibody
Characterization SOP Files
Background
Catalog Number:
CPTC-WWC2-2
Target Antigen:
WW And C2 Domain Containing 2
Isotype:
IgG2a
Species:
Mouse Monoclonal Antibody
Last Updated:
08/16/2023
Antigen Recognition(s):
Recombinant Full-length, Endogenous
Characterization Data [Compare Characterization Data]
Western Blot - Over-expressed transient protein in cell lysate
CPTC-WWC2-2 automated WB (over-expressed lysate)
Result: Positive
Automated Western Blot using antibody CPTC-WWC2-2 as primary antibody. The antibody was tested against overexpressed lysates of WWC1, WWC2 and WWC3. The antibody specifically recognizes the target WWC2.
Characterization SOP Files
Western Blot - Tissue or Cell Lysate
CPTC-WWC2-2 automated WB (lysate)
Result: Positive
Automated Western Blot using antibody CPTC-WWC2-2 as primary antibody. The antibody was tested against cell lysates of SF-539 and HS 578T. The antibody recognized the target protein in both cell lysates. The cell lysates were also tested with anti-Cytochrome C antibody.
Characterization SOP Files
Background
Catalog Number:
CPTC-WWC2-3
Target Antigen:
WW And C2 Domain Containing 2
Isotype:
IgG2b
Species:
Mouse Monoclonal Antibody
Last Updated:
08/16/2023
Antigen Recognition(s):
Peptide, Recombinant Full-length
Characterization Data [Compare Characterization Data]
Western Blot - Over-expressed transient protein in cell lysate
CPTC-WWC2-3 automated WB (over-expressed lysate)
Result: Positive
Automated Western Blot using antibody CPTC-WWC2-3 as primary antibody. The antibody was tested against overexpressed lysates of WWC1, WWC2 and WWC3. The antibody specifically recognizes the target WWC2.
Characterization SOP Files
Western Blot - Tissue or Cell Lysate
CPTC-WWC2-3 automated WB (lysate)
Result: Negative
Automated Western Blot using antibody CPTC-WWC2-3 as primary antibody. The antibody was tested against cell lysates of SF-539 and HS 578T. The antibody did not recognize the target protein in neither cell lysates. The cell lysates were also tested with anti-Cytochrome C antibody.
Characterization SOP Files
Background
NCI Identification Number:
00511
Antigen Name:
WW And C2 Domain Containing 2
CPTC Name:
CPTC-WWC2
Aliases:
WW And C2 Domain Containing 2; BOMB; WW, C2 And Coiled-Coil Domain Containing 2; Protein WWC2; FLJ22029; WW Domain-Containing Protein 2; BH3-Only Member B Protein; BH-3-Only Member B
Function:
This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling.WWC2 (WW And C2 Domain Containing 2) is a Protein Coding gene. Diseases associated with WWC2 include Van Maldergem Syndrome and Hennekam Syndrome. Gene Ontology (GO) annotations related to this gene include kinase binding and molecular adaptor activity. An important paralog of this gene is WWC1.
Chromosomal Localization:
4q35.1
Expression System:
E.coli
Accession Number:
NP_079225.5
UniProt Accession Number:
Q6AWC2
DNA Source:
N/A
Immunogen:
Recombinant Domain
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLS
FADCVGDELPWGWEAGFDPQIGVYYIDHINKTTQIEDPRKQWRGEQEKML
KDYLSVAQDALRTQKELYHVKEQRLALALDEYVRLNDAYKEKSSSHTSLF
SGSSSSTKYDPDILKAEISTTRLRVKKLKRELSQMKQELLYKEQGFETLQ
QIDKKMSGGQSGYELSEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQ
ERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRS
NLAEKVRLSLQYEEAKRSMANLKIELSKLDSEAWPGALDIEKEKLMLINE
KEELLKELQFVTPQKRTQDELERLEAERQRLEEELLSVRGTPSRALAERL
RLEERRKELLQKLEETTKLTTYLHSQLKSLSASTLSMSSGSSLGSLASSR
GSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDFLLQEKSGYIPSG
PITTIHENEVVKSPSQPGQSGLCGVAAAATGHTPPLAEAPKSVASLSSRS
SLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCELSSHFADISLI
ENQILLDSDSGGASQSLSEDKDLNECAREPLYEGTADVEKSLPKRRVIHL
LGEKTTCVSAAVSDESVAGDSGVYEAFVKQPSEMEDVTYSEEDVAIVETA
QVQIGLRYNAKSSSFMVIIAQLRNLHAFLIPHTSKVYFRVAVLPSSTDVS
CLFRTKVHPPTESILFNDVFRVAISQTALQQKTLRVDLCSVSKHRREECL
AGTQISLADLPFSSEVFTLWYNLLPSKQMPCKKNEENEDSVFQPNQPLVD
SIDLDAVSALLARTSAELLAVEQELAQEEEEESGQEEPRGPDGDWLTMLR
EASDEIVAEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDL
RSQPPTRIPTLVDKETNTDEAANDNMAVRPKERSSLSSRQHPFVRSSVIV
RSQTFSPGERNQYICRLNRSDSDSSTLAKKSLFVRNSTERRSLRVKRTVC
QSVLRRTTQECPVRTSLDLELDLQASLTRQSRLNDELQALRDLRQKLEEL
KAQGETDLPPGVLEDERFQRLLKQAEKQAEQSKEEQKQGLNAEKLMRQVS
KDVCRLREQSQKVPRQVQSFREKIAYFTRAKISIPSLPADDV
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
11
Last Updated:
02/17/2022
Links
- EnsEMBL - EnsEMBL WWC2
- Entrez - Entrez WWC2
- Uniprot - Uniprot Q6AWC2
Characterization Data
SOPs
No SOPs available.
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