Ubiquitin Conjugating Enzyme E2 T Peptide 1


Background

Catalog Number:

CPTC-UBE2T-1

Target Antigen:

Ubiquitin Conjugating Enzyme E2 T Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

04/26/2018

Antigen Recognition(s):

Peptide, Phosphorylation

SOP:

External Links
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-UBE2T-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3263) Click image to enlarge

CPTC-UBE2T-1 iMRM

Immuno-MRM chromatogram of CPTC-UBE2T-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3263)

Background

NCI Identification Number:

00202

Antigen Name:

Ubiquitin Conjugating Enzyme E2 T Peptide 1

CPTC Name:

CPTC-UBE2T Peptide 1

Keywords:

Ubiquitin Conjugating Enzyme E2 T; Cell Proliferation-Inducing Gene 50 Protein; E2 Ubiquitin-Conjugating Enzyme T; Ubiquitin Carrier Protein T; Ubiquitin-Protein Ligase T; HSPC150 Protein Similar To Ubiquitin-Conjugating Enzyme; Ubiquitin-Conjugating Enzyme E2T (Putative); Ubiquitin-Conjugating Enzyme E2 T; Ubiquitin-Conjugating Enzyme E2T; Ubiquitin Conjugating Enzyme E2T; EC 2.3.2.23; HSPC150; FANCT; PIG50

Function:

The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene.

UBE2T (Ubiquitin Conjugating Enzyme E2 T) is a Protein Coding gene. Diseases associated with UBE2T include Fanconi Anemia, Complementation Group T and Ube2t-Related Fanconi Anemia. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Fanconi anemia pathway. GO annotations related to this gene include chromatin binding and ubiquitin-protein transferase activity. An important paralog of this gene is UBE2N.

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer Lys-11-, Lys-27-, Lys-48- and Lys-63-linked polyubiquitination.

Chromosomal Localization:

1q32.1

NCBI Accession Number:

NP_001297255.1

Swiss Prot Accession Number:

Q9NPD8

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

A(pS)QLVGIEK (pS184)

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

990

Last Updated:

03/08/2018

Links

Characterization Data

SOPs

No SOPs available.

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