Transthyretin


Background

Catalog Number:

CPTC-TTR-1

Target Antigen:

Transthyretin

Isotype:

IgG2a

Species:

Mouse Monoclonal Antibody

Last Updated:

06/13/2017

Antigen Recognition(s):

recombinant full-length

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Characterization Data [Compare Characterization Data]
  Western Blot
Click to enlarge image Western Blot using CPTC-TTR-1 as primary Ab against TTR (Ag 11118) (lane 2). Also included are molecular wt. standards (lane 1) and mouse IgG control (lane 3). Click image to enlarge

CPTC-TTR-1 Western blot

Western Blot using CPTC-TTR-1 as primary Ab against TTR (Ag 11118) (lane 2). Also included are molecular wt. standards (lane 1) and mouse IgG control (lane 3).

  Indirect ELISA
Click to enlarge image Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding. Click image to enlarge

CPTC-TTR-1 Indirect ELISA

Indirect ELISA (ie, binding of Antibody to Antigen coated plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.

Characterization SOP Files

  NCI 60 Protein Array

CPTC-TTR-1 NCI 60 Protein Array

This antibody is not suitable for use in a Reverse Phase Protein Array format as described in SOP M-105.

  IHC NCI60

CPTC-TTR-1 IHC NCI60

This antibody is not suitable for use in an Immunohistochemistry format as described in SOP M-106.

Click to view IHC NCI60 Cell Line Array example
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IHC Cell Line Images

IHC NCI60 Cell Line Array example
  IHC Tissue
Click to enlarge image Tissue Micro-Array(TMA) core of breast cancer showing cytoplasmic staining using Antibody CPTC-TTR-1. Titer: 1:8000 Click image to enlarge

CPTC-TTR-1 IHC Tissue

Tissue Micro-Array(TMA) core of breast cancer showing cytoplasmic staining using Antibody CPTC-TTR-1. Titer: 1:8000

Background

NCI Identification Number:

11118

Antigen Name:

Transthyretin

CPTC Name:

CPTC-TTR

Keywords:

Transthyretin; PALB; HsT2651; prealbumin, amyloidosis type 1; ATTR; TBPA; CTS; CTS1; carpal tunnel syndrome 1; thyroxine-binding prealbumin; prealbumin

Function:

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Chromosomal Localization:

18q12.1

Expression System:

E. Coli

NCBI Accession Number:

BC005310

Swiss Prot Accession Number:

P02766

DNA Source:

HsCD00004170

Immunogen:

Recombinant Full Length Protein

Vector Name:

pMCSG7

Extinction Coefficient:

18450

Buffers:

PBS without Ca++ and Mg++

Expressed Sequence:

SNAPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGK
TSESGELHGLTTE

Native Sequence:

MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAV
HVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWK
ALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE

Calculated Isoelectric Point:

5.35

Molecular Weight:

13704

Last Updated:

08/31/2012

Links

Characterization Data

Gel

Click to enlarge image Tissue Micro-Array(TMA) core of breast cancer showing cytoplasmic staining using Antibody CPTC-TTR-1. Titer: 1:8000
Click image to enlarge

CPTC-TTR PAGE

PAGE of TTR (rAg 11118) with molecular weight standards in lane 1

SOPs

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