Topoisomerase (DNA) II Binding Protein 1 Peptide 2


Background

Catalog Number:

CPTC-TOPBP1-2

Target Antigen:

Topoisomerase (DNA) II Binding Protein 1 Peptide 2

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

04/26/2018

Antigen Recognition(s):

Peptide

SOP:

External Links
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-TOPBP1-2 antibody (see CPTAC assay portal for details:  https://assays.cancer.gov/CPTAC-3291) Click image to enlarge

CPTC-TOPBP1-2 iMRM

Immuno-MRM chromatogram of CPTC-TOPBP1-2 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3291)

Background

NCI Identification Number:

00230

Antigen Name:

Topoisomerase (DNA) II Binding Protein 1 Peptide 2

CPTC Name:

CPTC-TOPBP1 Peptide 2

Keywords:

Topoisomerase (DNA) II Binding Protein 1; DNA Topoisomerase II-Beta-Binding Protein 1; DNA Topoisomerase II-Binding Protein 1; DNA Topoisomerase 2-Binding Protein 1; KIAA0259; TOP2BP1; TopBP1

Function:

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.

TOPBP1 (Topoisomerase (DNA) II Binding Protein 1) is a Protein Coding gene. Diseases associated with TOPBP1 include Ataxia-Telangiectasia. Among its related pathways are BARD1 signaling events and DNA Double-Strand Break Repair. GO annotations related to this gene include identical protein binding and protein C-terminus binding. An important paralog of this gene is ECT2.

Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.

Chromosomal Localization:

3q22.1

NCBI Accession Number:

NP_008958.2

Swiss Prot Accession Number:

Q92547

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

QTVPDVNTEPSQNEQIIWDDPTAR

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

2640

Last Updated:

07/20/2017

Links

Characterization Data

SOPs

No SOPs available.

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