TIMP Metallopeptidase Inhibitor 1 Peptide 2


Background

Catalog Number:

CPTC-TIMP1-2

Target Antigen:

TIMP Metallopeptidase Inhibitor 1 Peptide 2

Isotype:

IgG

Species:

Rabbit Recombinant Cloned Antibody

Last Updated:

03/11/2021

Antigen Recognition(s):

Peptide

Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image iMRM screening of CPTC-TIMP1-2 against synthetic peptide SEEFLIAGK (TIMP Metallopeptidase Inhibitor 1 Peptide 2) Click image to enlarge

CPTC-TIMP1-2 iMRM screening (synthetic peptide)

Result: Positive

iMRM screening of CPTC-TIMP1-2 against synthetic peptide SEEFLIAGK (TIMP Metallopeptidase Inhibitor 1 Peptide 2)


Background

NCI Identification Number:

00328

Antigen Name:

TIMP Metallopeptidase Inhibitor 1 Peptide 2

CPTC Name:

CPTC-TIMP1 Peptide 2

Keywords:

TIMP Metallopeptidase Inhibitor 1; Tissue Inhibitor Of Metalloproteinases 1; Fibroblast Collagenase Inhibitor; Metalloproteinase Inhibitor 1; Collagenase Inhibitor; TIMP-1; CLGI; TIMP; EPO; EPA; Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating Activity, Collagenase Inhibitor); Epididymis Secretory Sperm Binding Protein; Erythroid Potentiating Activity; Erythroid-Potentiating Activity; TIMP1; HCI

Function:

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. TIMP1 (TIMP Metallopeptidase Inhibitor 1) is a Protein Coding gene. Diseases associated with TIMP1 include Oral Submucous Fibrosis and Lung Giant Cell Carcinoma. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include cytokine activity and protease binding. An important paralog of this gene is TIMP2.Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

Chromosomal Localization:

Xp11.3

NCBI Accession Number:

XP_016885255.1

UniProt Accession Number:

P01033

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

SEEFLIAGK

Native Sequence:

Calculated Isoelectric Point:

Molecular Weight:

990

Last Updated:

08/21/2020

Links

Characterization Data

SOPs

No SOPs available.

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