Transporter 1, ATP Binding Cassette Subfamily B Member Peptide 1

CPTC-TAP1-1

AB_2889968

Transporter 1, ATP Binding Cassette Subfamily B Member Peptide 1

IgG

Mouse Monoclonal Antibody

02/09/2024

Peptide, Endogenous

00398

Transporter 1, ATP Binding Cassette Subfamily B Member Peptide 1

CPTC-TAP1 Peptide 1

Transporter 1, ATP Binding Cassette Subfamily B Member; RING4; PSF1; Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP); Peptide Transporter Involved In Antigen Processing 1; ATP-Binding Cassette Sub-Family B Member 2; Really Interesting New Gene 4 Protein; Antigen Peptide Transporter 1; Peptide Transporter PSF1; Peptide Transporter TAP1; Peptide Supply Factor 1; D6S114E; ABCB2; PSF-1; APT1; Transporter, ATP-Binding Cassette, Major Histocompatibility Complex, 1; ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 2; Transporter 1 ATP-Binding Cassette Sub-Family B; Transporter Associated With Antigen Processing; ABC Transporter, MHC 1; TAP1*0102N; ABC17; TAP1N; TAP1; Y3

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. TAP1 (Transporter 1, ATP Binding Cassette Subfamily B Member) is a Protein Coding gene. Diseases associated with TAP1 include Immunodeficiency By Defective Expression Of Mhc Class I and Bare Lymphocyte Syndrome, Type I. Among its related pathways are Antigen processing-Cross presentation and MECP2 and Associated Rett Syndrome. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCB9.Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

6p21.32

NP_000584.3

Q03518

N/A

Synthetic Peptide

N/A

1650

09/02/2020