Background
NCI Identification Number:
00564
Antigen Name:
SLAM Family Member 7 Peptide 1
CPTC Name:
CPTC-SLAMF7 Peptide 1
Aliases:
SLAM Family Member 7; CRACC; CS1; CD319; 19A; Membrane Protein FOAP-12; CD2 Subset 1; Protein 19A; Novel LY9 (Lymphocyte Antigen 9) Like Protein; CD2-Like Receptor Activating Cytotoxic Cells; CD2-Like Receptor-Activating Cytotoxic Cells; 19A24 Protein; CD319 Antigen; Novel Ly9
Function:
Enables identical protein binding activity. Predicted to be involved in T cell activation. Predicted to act upstream of or within regulation of natural killer cell activation. Located in endoplasmic reticulum.SLAMF7 (SLAM Family Member 7) is a Protein Coding gene. Diseases associated with SLAMF7 include Plasmablastic Lymphoma and Smoldering Myeloma. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include signaling receptor activity. An important paralog of this gene is CD84.Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528). ( SLAF7_HUMAN,Q9NQ25). Isoform 3 does not mediate any NK cell activation. ( SLAF7_HUMAN,Q9NQ25).
Chromosomal Localization:
1q23.3
Accession Number:
UniProt Accession Number:
Q9NQ25
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
ELVGSVGGAVTFPLK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1650
Last Updated:
01/08/2025
Links
- EnsEMBL - EnsEMBL SLAMF7
- Uniprot - Uniprot Q9NQ25
Characterization Data
SOPs
No SOPs available.
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