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Ribonucleotide Reductase M2 Peptide 2

Antibody: CPTC-RRM2-2
Background

Catalog Number:

CPTC-RRM2-2

RRID:

AB_2617334

Target Antigen:

Ribonucleotide Reductase M2 Peptide 2

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

02/24/2025

Antigen Recognition(s):

Peptide, Recombinant Full-length

Thematic Panel(s):

DNA Damage Response (DDR) Pathway

External Links
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Characterization Data [Compare Characterization Data]
  IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (331.1 KB)

CPTC-RRM2-2 Evaluation by the Human Protein Atlas

Result: Negative

This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)


Characterization SOP Files

  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-RRM2-2 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-725).Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html). Data shown were obtained from plasma. Click image to enlarge

CPTC-RRM2-2 iMRM (plasma)

Result: Positive

Immuno-MRM chromatogram of CPTC-RRM2-2 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-725).Data provided by the Paulovich Lab, Fred Hutch (https://research.fredhutch.org/paulovich/en.html). Data shown were obtained from plasma.


Characterization SOP Files

  Indirect ELISA
Click to enlarge image Indirect ELISA (ie, binding of Antibody to biotinylated peptide coated on a NeutrAvidin plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding. Click image to enlarge

CPTC-RRM2-2 Indirect ELISA (peptide)

Result: High Binding

Indirect ELISA (ie, binding of Antibody to biotinylated peptide coated on a NeutrAvidin plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.


Characterization SOP Files

  Indirect ELISA
Click to enlarge image Indirect ELISA (ie, binding of Antibody to full-length Antigen coated on plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding. Click image to enlarge

CPTC-RRM2-2 Indirect ELISA

Result: High Binding

Indirect ELISA (ie, binding of Antibody to full-length Antigen coated on plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.


Characterization SOP Files

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Antigen: Ribonucleotide Reductase M2 Peptide 2
Background

NCI Identification Number:

00039

Antigen Name:

Ribonucleotide Reductase M2 Peptide 2

CPTC Name:

CPTC-RRM2 Peptide 2

Aliases:

Ribonucleotide Reductase M2 Polypeptide; Ribonucleotide Reductase Small Chain; Ribonucleotide Reductase Small Subunit; RR2; EC 1.17.4.1; R2; RR2M; Ribonucleoside-Diphosphate Reductase Subunit M2

Function:

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the
formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a
cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1
and X.

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.

Chromosomal Localization:

2p25-p24

Accession Number:

NP_001025.1

UniProt Accession Number:

P31350

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

DIQHWESLKPEER

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1430

Last Updated:

06/21/2013

Links

Characterization Data

SOPs

No SOPs available.

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