Replication Timing Regulatory Factor 1 Peptide 1


Background

Catalog Number:

CPTC-RIF1-1

Target Antigen:

Replication Timing Regulatory Factor 1 Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

10/22/2019

Antigen Recognition(s):

Peptide

Thematic Panel(s):

DNA Damage Response (DDR) Pathway

SOP:

External Links
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-RIF1-1 antibody (see CPTAC assay portal for details:  https://assays.cancer.gov/CPTAC-3254) Click image to enlarge

CPTC-RIF1-1 iMRM

Result: Positive

Immuno-MRM chromatogram of CPTC-RIF1-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-3254)


Background

NCI Identification Number:

00229

Antigen Name:

Replication Timing Regulatory Factor 1 Peptide 1

CPTC Name:

CPTC-RIF1 Peptide 1

Keywords:

Replication Timing Regulatory Factor 1; RAP1 Interacting Factor Homolog (Yeast); Rap1-Interacting Factor 1 Homolog

Function:

This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants.

RIF1 (Replication Timing Regulatory Factor 1) is a Protein Coding gene. Diseases associated with RIF1 include Candida Glabrata. Among its related pathways are DNA Double-Strand Break Repair and Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include binding.

Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints.

Chromosomal Localization:

2q23.3

NCBI Accession Number:

NP_001171134.1

Swiss Prot Accession Number:

Q5UIP0

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

ASQGLLSSIENSESDSSEAK

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

2200

Last Updated:

10/24/2019

Links

Characterization Data

SOPs

No SOPs available.

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