Background
Catalog Number:
CPTC-RECQL-1
Target Antigen:
RecQ Like Helicase Peptide 1
Isotype:
IgG
Species:
Rabbit Monoclonal Antibody
Last Updated:
02/24/2025
Antigen Recognition(s):
Peptide, Endogenous
Purchase
- DSHB CPTC-RECQL-1
External Links
- Human Protein Atlas CPTC-RECQL-1
Characterization Data [Compare Characterization Data]
IHC HPA
Download This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org) (158.9 KB)
CPTC-RECQL-1 Evaluation by the Human Protein Atlas
Result: Positive
This PDF contains the evaluation results provided by the Human Protein Atlas (www.proteinatlas.org)
Characterization SOP Files
Background
NCI Identification Number:
00442
Antigen Name:
RecQ Like Helicase Peptide 1
CPTC Name:
CPTC-RECQL Peptide 1
Aliases:
RecQ Like Helicase; RecQ1; RecQ Protein-Like (DNA Helicase Q1-Like); DNA Helicase, RecQ-Like Type 1; ATP-Dependent DNA Helicase Q1; DNA-Dependent ATPase Q1; RecQ Protein-Like 1; RecQ Helicase-Like; RECQL1; DNA Helicase Q1-Like; EC 3.6.4.12; EC 3.6.1; RecQL1; RECQL; RECQ1
Function:
The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. The encoded protein is involved in the processing of Holliday junctions, the suppression of sister chromatid exchanges, telomere maintenance, and is required for genotoxic stress resistance. Defects in this gene have been associated with several types of cancer. RECQL (RecQ Like Helicase) is a Protein Coding gene. Diseases associated with RECQL include Inherited Cancer-Predisposing Syndrome and Werner Syndrome. Among its related pathways are DNA Damage. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ATP-dependent DNA helicase activity. An important paralog of this gene is BLM.DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
Chromosomal Localization:
12p12.1
Accession Number:
NP_002898.2
UniProt Accession Number:
P46063
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
EVFLVMPTGGGK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1320
Last Updated:
09/30/2020
Links
- EnsEMBL - EnsEMBL RECQL
- Entrez - Entrez RECQL
- Uniprot - Uniprot P46063
Characterization Data
SOPs
No SOPs available.
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