Background
NCI Identification Number:
00597
Antigen Name:
RB Transcriptional Corepressor 1 Peptide 5
CPTC Name:
CPTC-RB1 Peptide 5
Aliases:
RB Transcriptional Corepressor 1; Retinoblastoma-Associated Protein; Retinoblastoma 1; PPP1R130; PRb; RB; Protein Phosphatase 1, Regulatory Subunit 130; Prepro-Retinoblastoma-Associated Protein; Retinoblastoma Suspectibility Protein; P110-RB1; P105-Rb; Pp110; Mutant Retinoblastoma-Associated Protein; Retinoblastoma Susceptibility Protein; Mutated Retinoblastoma Protein; Retinoblastoma; Osteosarcoma; RB1 Protein; Rb
Function:
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.RB1 (RB Transcriptional Corepressor 1) is a Protein Coding gene. Diseases associated with RB1 include Retinoblastoma and Familial Retinoblastoma. Among its related pathways are Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes and SARS-CoV-1 Genome Replication and Transcription. An important paralog of this gene is RBL2.
Chromosomal Localization:
13q14.2
Accession Number:
UniProt Accession Number:
P06400
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
ISEGLPTPTK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
1100
Last Updated:
07/01/2026
Links
- EnsEMBL - ensEMBL RB1
- Uniprot - Uniprot P06400
Characterization Data
SOPs
No SOPs available.
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