Background
NCI Identification Number:
00595
Antigen Name:
RAD50 Double Strand Break Repair Protein Peptide 3
CPTC Name:
CPTC-RAD50 Peptide 3
Aliases:
RAD50 Double Strand Break Repair Protein; DNA Repair Protein RAD50; HRad50; RAD50 Homolog, Double Strand Break Repair Protein; RAD50-2; RAD50 (S. Cerevisiae) Homolog; RAD50 Homolog (S. Cerevisiae); RAD50 Protein; RAD502; HRAD50; NBSLD
Function:
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.RAD50 (RAD50 Double Strand Break Repair Protein) is a Protein Coding gene. Diseases associated with RAD50 include Nijmegen Breakage Syndrome-Like Disorder and Inherited Cancer-Predisposing Syndrome. Among its related pathways are Sensing of DNA Double Strand Breaks and DDX1 as a regulatory component of the Drosha microprocessor.
Chromosomal Localization:
5q31.1
Accession Number:
UniProt Accession Number:
Q92878
DNA Source:
N/A
Immunogen:
Synthetic Peptide
Vector Name:
N/A
Extinction Coefficient:
Buffers:
Expressed Sequence:
GNTFVHDPK
Native Sequence:
Calculated Isoelectric Point:
Molecular Weight:
990
Last Updated:
07/01/2026
Links
- EnsEMBL - ensEMBL RAD50
- Uniprot - Uniprot Q92878
Characterization Data
SOPs
No SOPs available.
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