RAD18 Homolog Peptide 3


Background

Catalog Number:

CPTC-RAD18-4

Target Antigen:

RAD18 Homolog Peptide 3

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

04/26/2018

Antigen Recognition(s):

Peptide, Phosphorylation

SOP:

External Links
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-RAD18-4 antibody (see CPTAC assay portal for details:
https://assays.cancer.gov/CPTAC-3285) Click image to enlarge

CPTC-RAD18-4 iMRM

Immuno-MRM chromatogram of CPTC-RAD18-4 antibody (see CPTAC assay portal for details:
https://assays.cancer.gov/CPTAC-3285)

  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-RAD18-4 antibody (see CPTAC assay portal for details:
https://assays.cancer.gov/CPTAC-3285) Click image to enlarge

CPTC-RAD18-4 iMRM

Immuno-MRM chromatogram of CPTC-RAD18-4 antibody (see CPTAC assay portal for details:
https://assays.cancer.gov/CPTAC-3285)

Background

NCI Identification Number:

00200

Antigen Name:

RAD18 Homolog Peptide 3

CPTC Name:

CPTC-RAD18 Peptide 3

Keywords:

RAD18 Homolog (S. Cerevisiae); Postreplication Repair Protein RAD18; RNF73; hHR18; hRAD18; RING Finger Protein 73; E3 Ubiquitin-Protein Ligase RAD18; Postreplication Repair Protein HRAD18p; RAD18, S. Cerevisiae, Homolog; EC 6.3.2.

Function:

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.

RAD18 (RAD18 homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include damaged DNA binding and ubiquitin protein ligase binding.

E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity

Chromosomal Localization:

3p25-p24

NCBI Accession Number:

NP_064550.3

Swiss Prot Accession Number:

Q9NS91

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

NHLLQFALE(pS)PAK (pS99)

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1430

Last Updated:

03/08/2018

Links

Characterization Data

SOPs

No SOPs available.

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