Protein Tyrosine Phosphatase, Receptor Type C Peptide 1


Background

Catalog Number:

CPTC-PTPRC-1

Target Antigen:

Protein Tyrosine Phosphatase, Receptor Type C Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

05/09/2018

Antigen Recognition(s):

peptide

External Links
Characterization Data [Compare Characterization Data]
  Immuno-MRM
Click to enlarge image Immuno-MRM chromatogram of CPTC-PTPRC-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-1172) Click image to enlarge

CPTC-PTPRC-1 IMRM

Immuno-MRM chromatogram of CPTC-PTPRC-1 antibody (see CPTAC assay portal for details: https://assays.cancer.gov/CPTAC-1172)

Background

Catalog Number:

CPTC-PTPRC-2

Target Antigen:

Protein Tyrosine Phosphatase, Receptor Type C Peptide 1

Isotype:

IgG

Species:

Rabbit Monoclonal Antibody

Last Updated:

03/08/2018

Antigen Recognition(s):

peptide

Background

NCI Identification Number:

00252

Antigen Name:

Protein Tyrosine Phosphatase, Receptor Type C Peptide 1

CPTC Name:

CPTC-PTPRC Peptide 1

Keywords:

Protein Tyrosine Phosphatase, Receptor Type C; CD45 Antigen; CD45; L-CA; T200; Protein Tyrosine Phosphatase, Receptor Type, C Polypeptide; Receptor-Type Tyrosine-Protein Phosphatase C; T200 Leukocyte Common Antigen; Leukocyte Common Antigen; T200 Glycoprotein; EC 3.1.3.48; GP180;
CD45R; B220; LCA; LY5

Function:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

PTPRC (Protein Tyrosine Phosphatase, Receptor Type C) is a Protein Coding gene. Diseases associated with PTPRC include Severe Combined Immunodeficiency, T Cell-Negative, B-Cell/Natural Killer-Cell Positive and Hepatitis C Virus. Among its related pathways are TCR signaling (REACTOME) and TCR signaling in naive CD4+ T cells. GO annotations related to this gene include protein kinase binding and phosphatase activity. An important paralog of this gene is PTPRS.

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Chromosomal Localization:

1q31.3-q32.1

Expression System:

NCBI Accession Number:

NP_001254727.1

Swiss Prot Accession Number:

P08575

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

LFLAEFQSIPR

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1210

Last Updated:

02/26/2018

Links

Characterization Data

SOPs

No SOPs available.

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