Parathyroid Hormone Related Protein Peptide 1


Background

Catalog Number:

CPTC-PTHrP-1

Target Antigen:

Parathyroid Hormone Related Protein Peptide 1

Isotype:

IgG1

Species:

Mouse Monoclonal Antibody

Last Updated:

11/19/2015

Antigen Recognition(s):

Characterization Data [Compare Characterization Data]
  Indirect ELISA
Click to enlarge image Indirect peptide ELISA (ie, binding of Antibody to biotinylated peptide coated on a NeutrAvidin plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding. Click image to enlarge

CPTC-PTHrP-1 Indirect ELISA

Indirect peptide ELISA (ie, binding of Antibody to biotinylated peptide coated on a NeutrAvidin plate). Note: B50% represents the concentration of Ab required to generate 50% of maximum binding.

  IPMS
Click to enlarge image Immuno-Precipitation Mass Spectrometry using CPTC-PTHrP-1 antibody with CPTC-PTHrP peptide 1 as the target antigen. Click image to enlarge

CPTC-PTHrP-1 IPMS

Immuno-Precipitation Mass Spectrometry using CPTC-PTHrP-1 antibody with CPTC-PTHrP peptide 1 as the target antigen.

Background

NCI Identification Number:

00122

Antigen Name:

Parathyroid Hormone Related Protein Peptide 1

CPTC Name:

CPTC-PTHrP Peptide 1

Keywords:

Parathyroid Hormone-Like Hormone; Parathyroid Hormone-Like Hormone Preproprotein; Osteostatin; PTH-RP; PTHRP; BDE2; PLP; Parathyroid Hormone-Related Protein Preproprotein; Parathyroid Hormone-Like Related Protein; Parathyroid Hormone-Related Protein; Parathyroid Hormone-Like Protein; PTH-Related Protein; HHM; PTHR

Function:

The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone.

PTHLH (Parathyroid Hormone-Like Hormone) is a Protein Coding gene. Diseases associated with PTHLH include brachydactyly, type e2 and brachydactyly, type e. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity and peptide hormone receptor binding.

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1. Osteostatin is a potent inhibitor of osteoclastic bone resorption.

Chromosomal Localization:

12p12.1-p11.2

Expression System:

NCBI Accession Number:

NP_002811.1

Swiss Prot Accession Number:

P12272

DNA Source:

N/A

Immunogen:

Synthetic Peptide

Vector Name:

N/A

Extinction Coefficient:

Buffers:

Expressed Sequence:

AVSEHQLLHDKGKIQ

Native Sequence:

Calculated Isoelectric Point:

0

Molecular Weight:

1789

Last Updated:

11/17/2015

Links

Characterization Data

SOPs

No SOPs available.

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